{"id":"W1577210083","doi":"10.1111/j.1742-4658.2011.08459.x","title":"Ser/ Thr residues at α3/β5 loop of Gαs are important in morphine‐induced adenylyl cyclase sensitization but not mitogen‐activated protein kinase phosphorylation","year":2011,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; Tehran University of Medical Sciences and Health Services; University of Tehran","keywords":"Adenylyl cyclase; Protein kinase A; Phosphorylation; Chemistry; Sensitization; Dephosphorylation; Kinase; MAPK/ERK pathway; Molecular biology; Receptor; Opioid; Gs alpha subunit; Internal medicine; Pharmacology; Endocrinology; Biology; Biochemistry; Medicine; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007642654,0.0002822587,0.0001445006,0.00007496716,0.0001318564,0.000161143,0.0001409753,0.0002083917,0.001771889],"category_scores_gemma":[0.0001172854,0.00008684289,0.0003356817,0.00008547111,0.0002742755,0.0001518208,0.0001421536,0.0003500845,0.0004639819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001793459,"about_ca_system_score_gemma":0.0001466104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005429449,"about_ca_topic_score_gemma":0.0006710303,"domain_scores_codex":[0.9999501,0.00001034155,0.000005205152,0.00001022131,0.000008807337,0.00001530352],"domain_scores_gemma":[0.9999136,0.00001147018,0.00003590137,0.000009013434,0.000006688175,0.00002339725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006989089,0.00002365239,0.0005875505,0.0000492716,0.00001245123,0.000160103,0.00001962992,0.0001515374,0.9966788,0.0002063111,0.00003648546,0.001375368],"study_design_scores_gemma":[0.0001355549,0.0009180629,0.02675206,0.00002443488,0.00008277535,0.0009950929,0.00007766108,0.001571905,0.9649626,0.0002198957,0.004246671,0.00001331202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974947,0.0005784761,0.0007621766,0.0000853873,0.00002663583,0.00001329075,0.0001245688,0.00002004008,0.0008947467],"genre_scores_gemma":[0.9979656,0.0003502495,0.0005773063,0.00007367031,0.000007331759,0.000009204648,0.0001961247,0.000008125733,0.0008123826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001771889,"threshold_uncertainty_score":0.005927563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02399080018397512,"score_gpt":0.2307138375110043,"score_spread":0.2067230373270292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}