{"id":"W1577210083","doi":"10.1111/j.1742-4658.2011.08459.x","title":"Ser/ Thr residues at α3/β5 loop of Gαs are important in morphine‐induced adenylyl cyclase sensitization but not mitogen‐activated protein kinase phosphorylation","year":2011,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; Tehran University of Medical Sciences and Health Services; University of Tehran","keywords":"Adenylyl cyclase; Protein kinase A; Phosphorylation; Chemistry; Sensitization; Dephosphorylation; Kinase; MAPK/ERK pathway; Molecular biology; Receptor; Opioid; Gs alpha subunit; Internal medicine; Pharmacology; Endocrinology; Biology; Biochemistry; Medicine; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003615395,0.0001953989,0.0002296917,0.000107083,0.000116679,0.00002471666,0.0001225122,0.0002352289,0.0002688091],"category_scores_gemma":[0.0001383024,0.0001772005,0.0001102918,0.0001109703,0.00002605896,0.00001904115,0.0000617491,0.0002082266,0.000005696199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005694381,"about_ca_system_score_gemma":0.0000939892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001266408,"about_ca_topic_score_gemma":0.0001500877,"domain_scores_codex":[0.9985702,0.0001188282,0.0005498822,0.0002713145,0.0002337459,0.0002560541],"domain_scores_gemma":[0.9988632,0.000007396358,0.0005677085,0.0002113966,0.0002315742,0.0001187235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007739189,0.00007092506,0.005681631,0.00002005798,0.00004081067,0.00006750037,0.0002287012,0.00007595234,0.9926996,0.0000175099,0.00008122856,0.000242131],"study_design_scores_gemma":[0.000845768,0.0002612556,0.01008905,0.0001254215,0.00001718928,0.00009514337,0.0001697889,0.0001890731,0.9877466,0.0002093142,0.00004679751,0.0002046275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984316,0.000311485,0.000615327,0.00006415307,0.0002166655,0.0002526365,0.00001952864,0.000007889626,0.00008073101],"genre_scores_gemma":[0.9982604,0.0001362062,0.0007928164,0.00004504274,0.0002130622,0.000008124018,0.00006324554,0.00003359072,0.0004474523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004953063,"threshold_uncertainty_score":0.7226027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02399080018397512,"score_gpt":0.2307138375110043,"score_spread":0.2067230373270292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}