{"id":"W1577535871","doi":"10.1113/jphysiol.2011.218156","title":"Losartan abolishes oxidative stress induced by intermittent hypoxia in humans","year":2011,"lang":"en","type":"article","venue":"The Journal of Physiology","topic":"High Altitude and Hypoxia","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Health Research Board; Heart and Stroke Foundation of Canada","keywords":"Losartan; Oxidative stress; Peroxynitrite; Chemistry; Endocrinology; Angiotensin II; Intermittent hypoxia; Internal medicine; Reactive oxygen species; Pharmacology; Receptor; Medicine; Biochemistry; Superoxide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002438742,0.0002501846,0.0005539281,0.0001050868,0.0001943178,0.0002126666,0.0001386126,0.000201487,0.0007794853],"category_scores_gemma":[0.0003636454,0.0001078548,0.0001960656,0.00006188604,0.0001938387,0.0001418315,0.0001565347,0.0004730816,0.0001027227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007976583,"about_ca_system_score_gemma":0.0001921474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003103778,"about_ca_topic_score_gemma":0.0004470799,"domain_scores_codex":[0.9998957,0.00003574613,0.000007846372,0.00001509415,0.00001766123,0.00002798672],"domain_scores_gemma":[0.9998312,0.00003295713,0.00004335393,0.00001596559,0.00001067683,0.00006574471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1635533,0.01313848,0.03674262,0.0007125761,0.000734627,0.001480208,0.0003689847,0.0007725398,0.5989468,0.0004273319,0.001352415,0.18177],"study_design_scores_gemma":[0.01581869,0.3174675,0.5497507,0.0001022579,0.001016436,0.002096098,0.0003385177,0.002893285,0.1003818,0.0007537268,0.009310391,0.00007059207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977398,0.0009697382,0.0005825819,0.00008818669,0.00006264553,0.00003558361,0.0000329175,0.00002634487,0.0004622143],"genre_scores_gemma":[0.9988795,0.0003666834,0.0001995391,0.00008062246,0.00006138202,0.00002317085,0.00005265029,0.000003449262,0.0003330395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007794853,"threshold_uncertainty_score":0.002607644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02087783817316927,"score_gpt":0.2554402847032826,"score_spread":0.2345624465301133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}