{"id":"W1577535871","doi":"10.1113/jphysiol.2011.218156","title":"Losartan abolishes oxidative stress induced by intermittent hypoxia in humans","year":2011,"lang":"en","type":"article","venue":"The Journal of Physiology","topic":"High Altitude and Hypoxia","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Health Research Board; Heart and Stroke Foundation of Canada","keywords":"Losartan; Oxidative stress; Peroxynitrite; Chemistry; Endocrinology; Angiotensin II; Intermittent hypoxia; Internal medicine; Reactive oxygen species; Pharmacology; Receptor; Medicine; Biochemistry; Superoxide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002153935,0.0001176557,0.000208294,0.00004559815,0.00003881101,0.000004359958,0.0004074609,0.0001002639,0.00006737278],"category_scores_gemma":[0.00003522516,0.00007616382,0.00007478009,0.00005208486,0.0001085207,0.000007666715,0.00008998219,0.0002209363,0.000008442335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009842181,"about_ca_system_score_gemma":0.00004124482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006320531,"about_ca_topic_score_gemma":0.0001287213,"domain_scores_codex":[0.999128,0.0001994702,0.0002956236,0.0001122367,0.00007261792,0.0001920663],"domain_scores_gemma":[0.999408,0.00001864126,0.0002325768,0.0002078076,0.0000831901,0.0000498057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000430476,0.0001494527,0.0007047664,0.000004396034,0.00007412259,0.000002912979,0.0007592922,0.000003418007,0.9961077,0.00005885527,0.001506681,0.0001979533],"study_design_scores_gemma":[0.0007428151,0.001844739,0.1487839,0.00002716514,0.00003713607,0.0000154018,0.000711449,0.000001767489,0.8451931,0.0007670511,0.001724151,0.0001513145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986465,0.0004672344,0.00003115501,0.00007002686,0.0001576088,0.00006306546,0.000008114323,0.000001696294,0.00055458],"genre_scores_gemma":[0.9991438,0.000252314,0.00004960557,0.0002652815,0.0002020895,0.000002066016,0.00000890197,0.00001090964,0.00006497744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1509146,"threshold_uncertainty_score":0.310587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02087783817316927,"score_gpt":0.2554402847032826,"score_spread":0.2345624465301133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}