{"id":"W1577584533","doi":"10.1126/scisignal.2004785","title":"The Adaptor Protein p66Shc Inhibits mTOR-Dependent Anabolic Metabolism","year":2014,"lang":"en","type":"article","venue":"Science Signaling","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Diabetes Canada; University of Toronto; Mount Sinai Hospital","funders":"National Cancer Institute; National Institute on Aging; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Anabolism; PI3K/AKT/mTOR pathway; Signal transducing adaptor protein; Carbohydrate metabolism; Insulin receptor; Mediator; Glycolysis; Signal transduction; Metabolism; Cell biology; Biology; Glucose uptake; Mechanistic target of rapamycin; Chemistry; Biochemistry; Insulin resistance; Insulin; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001197105,0.0003140473,0.0001520442,0.0002783474,0.000198732,0.0002663643,0.0001631208,0.0002383969,0.001064258],"category_scores_gemma":[0.0001360904,0.0001086726,0.0001392388,0.0002116834,0.0002770437,0.000156335,0.0002683953,0.000505246,0.0002782943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002635442,"about_ca_system_score_gemma":0.0003454758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005959317,"about_ca_topic_score_gemma":0.0008493326,"domain_scores_codex":[0.9999015,0.0000135951,0.000007987322,0.00001293234,0.00002926298,0.00003476557],"domain_scores_gemma":[0.9999079,0.00001701432,0.0000252728,0.0000122094,0.000009538215,0.00002810646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002642828,0.00003888947,0.0003052253,0.00003502155,0.000006988389,0.0000494657,0.000006170656,0.0001577886,0.9952442,0.0003549396,0.0001838403,0.003353093],"study_design_scores_gemma":[0.00004013895,0.0003522702,0.004399636,0.000005659492,0.00001317349,0.0001732907,0.00001645848,0.001699184,0.9900231,0.000152879,0.003119696,0.000004465611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932539,0.002295635,0.001630435,0.000275002,0.00004421573,0.00001529209,0.0002401654,0.0001318642,0.002113601],"genre_scores_gemma":[0.9971555,0.00091282,0.000606486,0.00004729638,0.000009967508,0.00001355604,0.0002146259,0.0000117447,0.001027915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001064258,"threshold_uncertainty_score":0.003560364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008895133590052657,"score_gpt":0.2396798927813486,"score_spread":0.230784759191296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}