{"id":"W1577584533","doi":"10.1126/scisignal.2004785","title":"The Adaptor Protein p66Shc Inhibits mTOR-Dependent Anabolic Metabolism","year":2014,"lang":"en","type":"article","venue":"Science Signaling","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Diabetes Canada; University of Toronto; Mount Sinai Hospital","funders":"National Cancer Institute; National Institute on Aging; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Anabolism; PI3K/AKT/mTOR pathway; Signal transducing adaptor protein; Carbohydrate metabolism; Insulin receptor; Mediator; Glycolysis; Signal transduction; Metabolism; Cell biology; Biology; Glucose uptake; Mechanistic target of rapamycin; Chemistry; Biochemistry; Insulin resistance; Insulin; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001861429,0.0001838195,0.0001631692,0.00007223366,0.0007774659,0.0001968966,0.0007063018,0.00008195061,0.00001027018],"category_scores_gemma":[0.0004208157,0.0001327362,0.00009658741,0.0003574706,0.0005264108,0.00001858352,0.0002229611,0.0001385774,0.00001983239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001827648,"about_ca_system_score_gemma":0.0003397947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004997353,"about_ca_topic_score_gemma":0.00004143506,"domain_scores_codex":[0.9979455,0.00009317273,0.0002481454,0.0005630979,0.000545838,0.000604242],"domain_scores_gemma":[0.9989025,0.00001638092,0.0001250161,0.0005482266,0.0002097598,0.0001981448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001908551,0.00001167985,0.00001438141,0.000003563209,0.000007547968,1.214127e-7,0.00005791645,0.00008884097,0.9853811,0.002016811,0.0002120849,0.0121869],"study_design_scores_gemma":[0.0002778757,0.00004098594,0.0002276603,0.00001088754,0.00001141664,0.000004903605,0.00009268431,0.000119546,0.7769188,0.0003243118,0.2217933,0.0001777003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895818,0.004503802,0.001954631,0.0002548317,0.001579686,0.0003451147,0.000008179935,0.00002876294,0.001743227],"genre_scores_gemma":[0.9948069,0.0001636817,0.000620659,0.0002957444,0.0028595,0.00005321145,0.000004140967,0.00002041309,0.001175759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2215812,"threshold_uncertainty_score":0.5979717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008895133590052657,"score_gpt":0.2396798927813486,"score_spread":0.230784759191296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}