{"id":"W1577695612","doi":"10.1096/fasebj.28.1_supplement.lb164","title":"Mitochondrial integrity is impaired in MELAS patients (LB164)","year":2014,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Occupational Cancer Research Centre; McMaster University; York University","funders":"","keywords":"FIS1; mitochondrial fusion; Mitochondrial fission; DNAJA3; Biology; Mitochondrion; Mitochondrial DNA; Mitochondrial myopathy; Cell biology; Mitochondrial apoptosis-induced channel; Lactic acidosis; Mitochondrial disease; Cytochrome c oxidase; PINK1; Inner mitochondrial membrane; Molecular biology; Mitophagy; Biochemistry; Apoptosis; Autophagy; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001474621,0.0007375319,0.0004093577,0.001025222,0.0004487673,0.0004920081,0.0002297499,0.0007119916,0.004176336],"category_scores_gemma":[0.000554324,0.0001520219,0.0002588074,0.0004919528,0.0002742742,0.0002650089,0.0003910323,0.0003940056,0.0007914776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002151284,"about_ca_system_score_gemma":0.0001123221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008097513,"about_ca_topic_score_gemma":0.0006363216,"domain_scores_codex":[0.9999005,0.00001501641,0.00001778931,0.00003085832,0.00002025686,0.00001564144],"domain_scores_gemma":[0.9997618,0.0000213296,0.0001063728,0.00001054105,0.00002397232,0.00007603138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008275449,0.0005267002,0.3357435,0.000384668,0.0002001855,0.09355209,0.0008743868,0.0002492307,0.523046,0.0004772583,0.001984917,0.03468554],"study_design_scores_gemma":[0.0002793225,0.0027687,0.7754474,0.0001137253,0.0001965506,0.1897851,0.0007185386,0.0008342561,0.02344037,0.0006477995,0.005725139,0.000043204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976897,0.0004631655,0.0003136657,0.0002183729,0.00002022679,0.00001644257,0.0003912723,0.00005473915,0.0008324604],"genre_scores_gemma":[0.9985135,0.0001842083,0.0002611858,0.00005729213,0.00001773596,0.00001081298,0.0003734057,0.000008413262,0.000573471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004176336,"threshold_uncertainty_score":0.01397127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01265124756308332,"score_gpt":0.2408806556815531,"score_spread":0.2282294081184698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}