{"id":"W1577912533","doi":"10.1002/jps.24460","title":"In Vivo Predictive Dissolution: Comparing the Effect of Bicarbonate and Phosphate Buffer on the Dissolution of Weak Acids and Weak Bases","year":2015,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":93,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Food and Drug Administration; United States Pharmacopeia; U.S. Food and Drug Administration; Hamilton Health Sciences Foundation; Universidade de São Paulo; U.S. Public Health Service; AstraZeneca","keywords":"Dissolution; Bicarbonate; Chemistry; Phosphate buffered saline; Buffer (optical fiber); Phosphate; In vivo; Chromatography; Biochemistry; Organic chemistry; Computer science; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001296895,0.0006512176,0.000810363,0.0003669773,0.0002357057,0.0007893904,0.0006406258,0.0005806169,0.00113157],"category_scores_gemma":[0.002317575,0.000381208,0.0004459073,0.0003899093,0.0005487896,0.0007343923,0.0003801414,0.001144405,0.0002073664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005096297,"about_ca_system_score_gemma":0.001164127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004001849,"about_ca_topic_score_gemma":0.002593873,"domain_scores_codex":[0.9993461,0.0002137746,0.00004238848,0.0001100692,0.0002347174,0.00005295564],"domain_scores_gemma":[0.9987401,0.0005790744,0.000283916,0.0001083553,0.0001652455,0.0001232883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03995386,0.001857856,0.002912959,0.0004563273,0.0001187722,0.000102539,0.0002092082,0.002384861,0.9264985,0.0002587294,0.0002958349,0.02495061],"study_design_scores_gemma":[0.0003589085,0.01289092,0.004090024,0.00001266781,0.0001922522,0.000200177,0.000072287,0.01018724,0.9707774,0.00005209096,0.001131404,0.0000346496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910347,0.002457332,0.005131135,0.0001176344,0.00006470172,0.0001343547,0.0003364793,0.00005890434,0.0006646588],"genre_scores_gemma":[0.9865435,0.003581682,0.007883346,0.00005607854,0.00003320731,0.00006400706,0.0003947129,0.00004862978,0.001394779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004001849,"threshold_uncertainty_score":0.007957101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1234527852431901,"score_gpt":0.4200745331317749,"score_spread":0.2966217478885848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}