{"id":"W1578107273","doi":"10.2741/s102","title":"Broad-spectrum and virus-specific nucleic acid-based antivirals against influenza","year":2009,"lang":"en","type":"review","venue":"Frontiers in Bioscience-Scholar","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Defence Research and Development Canada","funders":"Centers for Disease Control and Prevention","keywords":"Nucleic acid; Virology; Biology; RNA; Influenza A virus; Oligonucleotide; Virus; Deoxyribozyme; Gene silencing; Innate immune system; Small interfering RNA; Viral replication; RNA interference; Gene; DNA; Immune system; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003787137,0.0007975948,0.00075556,0.001082472,0.0002737392,0.0004413454,0.0006432928,0.0007884311,0.002838613],"category_scores_gemma":[0.0002594448,0.0002087688,0.000208809,0.00116874,0.0004542611,0.001025374,0.0003898323,0.001110121,0.003004783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005086588,"about_ca_system_score_gemma":0.000498124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005589739,"about_ca_topic_score_gemma":0.001218077,"domain_scores_codex":[0.9999031,0.00001553629,0.000008795693,0.00001717866,0.00004423399,0.00001111934],"domain_scores_gemma":[0.9999207,0.00002564122,0.00001100843,0.000003638363,0.00002522251,0.00001376222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007990062,0.0000962717,0.00009580688,0.004458388,0.00003020027,0.0002018177,0.00005239371,0.0005052126,0.01066553,0.005845688,0.02977841,0.9481904],"study_design_scores_gemma":[0.00001686612,0.00008503169,0.000376654,0.000524965,0.00001450386,0.0006663183,0.00002730823,0.00009351755,0.001696901,0.001719266,0.9947709,0.000007801639],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004414938,0.9936128,0.0006137624,0.0002796925,0.0004011613,0.00001125207,0.00001203104,0.00001650282,0.004611217],"genre_scores_gemma":[0.00249721,0.9914116,0.000791077,0.0002217665,0.0002763331,0.00001681205,0.00003508386,0.000002804377,0.004747356],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002838613,"threshold_uncertainty_score":0.009496093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0315363467695841,"score_gpt":0.2911794094730061,"score_spread":0.259643062703422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}