{"id":"W1578622542","doi":"10.4049/jimmunol.180.12.8461","title":"Novel Vaccination for Allergy through Gene Silencing of CD40 Using Small Interfering RNA","year":2008,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Hospital; Lawson Health Research Institute; Western University","funders":"","keywords":"Gene silencing; Small interfering RNA; RNA interference; Immune system; Immunology; Allergy; CD40; Biology; Gene; RNA; Cytotoxic T cell; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002041484,0.0004306106,0.0003682881,0.0002661209,0.0001533717,0.0002908022,0.0002830083,0.000688096,0.001013211],"category_scores_gemma":[0.00008616581,0.0001450843,0.0003567616,0.00009081426,0.0002983735,0.0003372753,0.0001832752,0.0006882964,0.0002988213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002168925,"about_ca_system_score_gemma":0.0002125324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001695601,"about_ca_topic_score_gemma":0.0003256888,"domain_scores_codex":[0.9998946,0.00001362865,0.000009055784,0.00002411672,0.00003687552,0.00002167982],"domain_scores_gemma":[0.999957,0.000009993957,0.00001179079,0.000004999593,0.000006456061,0.000009839652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000500668,0.00009680161,0.0000681367,0.00005773489,0.000007643246,0.00007684559,0.000007530764,0.00005834041,0.9938123,0.0002269812,0.0001239169,0.005413473],"study_design_scores_gemma":[0.0001137023,0.001563468,0.001157353,0.00001197951,0.00007518432,0.001200232,0.00001135071,0.001468581,0.9822124,0.0001814802,0.01199336,0.0000108498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9087312,0.01982202,0.06407266,0.001229294,0.000517397,0.0004170641,0.0002672891,0.0007648915,0.004178216],"genre_scores_gemma":[0.9551656,0.009161419,0.02907952,0.0004726214,0.0001710101,0.0002395432,0.0003924231,0.00004565915,0.005272231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001013211,"threshold_uncertainty_score":0.003389537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05032764141326219,"score_gpt":0.2678054580992104,"score_spread":0.2174778166859482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}