{"id":"W1578644950","doi":"10.1111/j.1476-5381.2012.02041.x","title":"Pseudohalide anions reveal a novel extracellular site for potentiators to increase CFTR function","year":2012,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Cystic Fibrosis Canada","keywords":"Potentiator; Cystic fibrosis transmembrane conductance regulator; Cystic fibrosis; Extracellular; Chemistry; Secretion; Biophysics; Ivacaftor; Mutagenesis; Biochemistry; Cell biology; Patch clamp; Mutant; Pharmacology; Internal medicine; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003797672,0.0003834021,0.0006162564,0.000147256,0.0001955799,0.0004293738,0.000729924,0.00113873,0.002481625],"category_scores_gemma":[0.0003859683,0.0001816854,0.0005780201,0.00008754106,0.0004819765,0.0005325774,0.0005796244,0.0009310844,0.000664454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002112936,"about_ca_system_score_gemma":0.0002622786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001230428,"about_ca_topic_score_gemma":0.0002378762,"domain_scores_codex":[0.999674,0.00007596317,0.0000241321,0.00004935058,0.0001168438,0.00005970173],"domain_scores_gemma":[0.9996899,0.0001045688,0.00007170023,0.0000358207,0.00005623228,0.00004170173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004183455,0.00002976451,0.0001708721,0.0001112571,0.000007789181,0.0001935186,0.00001102435,0.0000815359,0.9961334,0.0003813776,0.00005151569,0.002409465],"study_design_scores_gemma":[0.000112622,0.001452368,0.002898358,0.00001643956,0.00003465562,0.001472085,0.00003182345,0.0008395656,0.9891092,0.0002426523,0.003778189,0.0000120467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9412055,0.01245884,0.03581775,0.001142123,0.0003756644,0.0003398998,0.0003789999,0.0003519883,0.00792924],"genre_scores_gemma":[0.9754227,0.00299785,0.0184613,0.0006111101,0.0001469886,0.0001259498,0.0001968375,0.00003808933,0.001999227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002481625,"threshold_uncertainty_score":0.008301914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02131291995126451,"score_gpt":0.3374578254982032,"score_spread":0.3161449055469387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}