{"id":"W1578768687","doi":"10.4049/jimmunol.172.6.3758","title":"The Human Cationic Peptide LL-37 Induces Activation of the Extracellular Signal-Regulated Kinase and p38 Kinase Pathways in Primary Human Monocytes","year":2004,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":236,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Children's & Women's Health Centre of British Columbia; University of British Columbia","funders":"","keywords":"Cell biology; p38 mitogen-activated protein kinases; Kinase; Phosphorylation; Signal transduction; Secretion; Biology; Chemokine; Molecular biology; Protein kinase A; Receptor; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008127279,0.0001852758,0.0003407022,0.000107342,0.0007558832,0.0000228599,0.000534649,0.0002107532,0.00003253755],"category_scores_gemma":[0.00006149341,0.00009911406,0.0001148792,0.000166302,0.001175887,0.0001960276,0.0001618928,0.0007560804,0.000004096078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001235324,"about_ca_system_score_gemma":0.0001521364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004671058,"about_ca_topic_score_gemma":0.00009214275,"domain_scores_codex":[0.9983367,0.0005440516,0.0006566074,0.0001197883,0.00005692124,0.0002859849],"domain_scores_gemma":[0.9983373,0.0003159946,0.00089024,0.0003140128,0.0001315624,0.00001094507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002018334,0.000141325,0.0003347146,0.0000111033,0.000189679,0.000003044272,0.001641278,0.000205657,0.9925342,0.003194869,0.00007873278,0.001463595],"study_design_scores_gemma":[0.001668704,0.0003873073,0.07483433,0.0001874369,0.0000737577,0.0002170974,0.002046486,7.251926e-7,0.9150937,0.005050433,0.0003156936,0.0001242882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899728,0.008334841,0.00002922878,0.001144521,0.000173151,0.0002132727,0.000004567528,0.000008617028,0.0001189813],"genre_scores_gemma":[0.9988522,0.0006487367,0.00001652771,0.00006950686,0.00003296198,0.000003296043,0.000008076617,0.00001560371,0.0003531237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07744043,"threshold_uncertainty_score":0.5813719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01483238134469959,"score_gpt":0.2198043349892494,"score_spread":0.2049719536445498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}