{"id":"W1579391006","doi":"10.1111/j.1476-5381.2012.01903.x","title":"Sirtuin 6 protects cardiomyocytes from hypertrophy <i>in vitro</i> via inhibition of NF‐κB‐dependent transcriptional activity","year":2012,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Key New Drug Creation and Manufacturing Program, Ministry of Science and Technology; Canadian Institutes of Health Research; National Science and Technology Major Project; National Natural Science Foundation of China","keywords":"Sirtuin; Transfection; Chemistry; Sirtuin 1; Muscle hypertrophy; HDAC4; Angiotensin II; Cell biology; NF-κB; Endocrinology; Downregulation and upregulation; Internal medicine; Biology; Signal transduction; Gene expression; NAD+ kinase; Medicine; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002452916,0.0005022929,0.0004321523,0.0001604174,0.0001684501,0.0002498028,0.0002424824,0.0002650599,0.001913544],"category_scores_gemma":[0.0001317039,0.0001268818,0.0005373381,0.0001210457,0.0003131211,0.0002313518,0.0001797273,0.0007561806,0.0005070625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001942046,"about_ca_system_score_gemma":0.0002002237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003103435,"about_ca_topic_score_gemma":0.0004486687,"domain_scores_codex":[0.9998804,0.00002121996,0.00001512331,0.00002066926,0.000033546,0.00002908613],"domain_scores_gemma":[0.9998956,0.00001179547,0.00003508042,0.00001605636,0.0000156837,0.00002575682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004285452,0.00005993203,0.0002692089,0.0001745342,0.00002513807,0.00003479713,0.00001408876,0.00005064744,0.9967288,0.00005402607,0.00009287892,0.002067268],"study_design_scores_gemma":[0.0001026385,0.001419318,0.007457976,0.0000232506,0.00008248848,0.0002935696,0.00003725647,0.0006221106,0.9862446,0.00007345507,0.003633547,0.000009802894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9656124,0.02139841,0.00776505,0.0005467098,0.0004648054,0.00005931549,0.0006433073,0.0004333918,0.003076624],"genre_scores_gemma":[0.9892684,0.005659433,0.002070078,0.0002228134,0.0001056917,0.00004092642,0.0007110246,0.00002838201,0.001893228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001913544,"threshold_uncertainty_score":0.006401479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01395051510373719,"score_gpt":0.2704823020403613,"score_spread":0.2565317869366241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}