{"id":"W1579991761","doi":"10.1111/febs.13309","title":"β‐Estradiol results in a proprotein convertase subtilisin/kexin type 9‐dependent increase in low‐density lipoprotein receptor levels in human hepatic HuH7 cells","year":2015,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"PCSK9; LDL receptor; Downregulation and upregulation; Kexin; Endocrinology; Internal medicine; Proprotein convertase; Low-density lipoprotein; Lipoprotein; Chemistry; Biology; Cholesterol; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002328564,0.0002788449,0.0003753489,0.0001811956,0.0001761996,0.0002743793,0.000141898,0.0001849496,0.003114512],"category_scores_gemma":[0.00009307615,0.0002163043,0.0004133324,0.0002346357,0.0001606973,0.00009413942,0.0001755903,0.0006156179,0.001416138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002026758,"about_ca_system_score_gemma":0.0002049006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001631819,"about_ca_topic_score_gemma":0.001936021,"domain_scores_codex":[0.9996496,0.00004754839,0.00005655889,0.00005916167,0.0001192261,0.00006786348],"domain_scores_gemma":[0.9998863,0.00003017358,0.0000158471,0.0000250802,0.00002147485,0.00002115809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002598317,0.0001045293,0.0004499273,0.00009293354,0.00001637397,0.0001166645,0.00005147483,0.00004999819,0.9968957,0.00008708139,0.0002422931,0.001633202],"study_design_scores_gemma":[0.00003333159,0.0004020667,0.007998785,0.000008077977,0.00002166948,0.0001834166,0.00005272368,0.0004933166,0.9861644,0.00002852427,0.004606142,0.000007585085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839492,0.003793632,0.00362229,0.0003084261,0.0002037144,0.00007994263,0.002780131,0.0001876472,0.005074884],"genre_scores_gemma":[0.9609142,0.003983094,0.006146302,0.0002749039,0.00005205088,0.0002253034,0.007538162,0.00005771164,0.02080834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003114512,"threshold_uncertainty_score":0.01041913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03687735548525903,"score_gpt":0.2840532923355609,"score_spread":0.2471759368503019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}