{"id":"W1581242854","doi":"10.4049/jimmunol.0803851","title":"Inhibition of ERK MAPK Suppresses IL-23- and IL-1-Driven IL-17 Production and Attenuates Autoimmune Disease","year":2009,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"","keywords":"MAPK/ERK pathway; Experimental autoimmune encephalomyelitis; Immunology; Innate immune system; Immune system; Cell biology; Biology; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003564809,0.0001842451,0.0003993934,0.0001688992,0.0001978595,0.00000932294,0.0001435571,0.0001540489,0.00004738156],"category_scores_gemma":[0.0001547213,0.0001225071,0.00008187753,0.0001051117,0.0004473455,0.0001819756,0.00005968238,0.0002393621,0.00001275687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002176659,"about_ca_system_score_gemma":0.00005128703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001679305,"about_ca_topic_score_gemma":0.00000677982,"domain_scores_codex":[0.9987237,0.0004041764,0.0004538677,0.0001466518,0.00004373466,0.0002278123],"domain_scores_gemma":[0.9989401,0.0001623316,0.0004816259,0.0002383996,0.0001546583,0.00002289954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00208701,0.0002237248,0.001908015,0.00001754375,0.0005030147,0.00001469321,0.001008938,0.00001361391,0.9715701,0.0001426721,0.001064865,0.02144576],"study_design_scores_gemma":[0.002751353,0.001918189,0.5014156,0.000230428,0.000984367,0.001485298,0.0008048146,0.000002429165,0.4849163,0.002026165,0.003232559,0.000232491],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9643992,0.03195297,0.000016679,0.002832259,0.0005236383,0.0001627003,0.00005154262,0.00001605918,0.00004495624],"genre_scores_gemma":[0.9912115,0.00805268,0.00006524332,0.00005983365,0.00006449801,0.00000282778,0.00003208847,0.000009669344,0.0005016583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4995076,"threshold_uncertainty_score":0.4995697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01127324377598136,"score_gpt":0.2230165687000897,"score_spread":0.2117433249241084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}