{"id":"W1581242854","doi":"10.4049/jimmunol.0803851","title":"Inhibition of ERK MAPK Suppresses IL-23- and IL-1-Driven IL-17 Production and Attenuates Autoimmune Disease","year":2009,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"","keywords":"MAPK/ERK pathway; Experimental autoimmune encephalomyelitis; Immunology; Innate immune system; Immune system; Cell biology; Biology; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001289466,0.0005736426,0.0004598254,0.0002101895,0.0001241692,0.0002388041,0.0002269594,0.0001913153,0.001447429],"category_scores_gemma":[0.0001373099,0.0001282605,0.0002536401,0.0001195304,0.0002447186,0.0002027972,0.000158149,0.0007763156,0.0004393755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001544729,"about_ca_system_score_gemma":0.0003238468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002726683,"about_ca_topic_score_gemma":0.0005286147,"domain_scores_codex":[0.9998606,0.00002484993,0.0000142558,0.00001348245,0.00003016998,0.00005654316],"domain_scores_gemma":[0.9999236,0.00001135155,0.00002081917,0.000007923797,0.000008211222,0.00002799202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001366835,0.0006402143,0.0002280781,0.0001399854,0.0000259048,0.00009896169,0.00001944146,0.0002621472,0.9901835,0.000156532,0.0002236733,0.006654659],"study_design_scores_gemma":[0.000275757,0.002923685,0.006514761,0.00002358518,0.00007208144,0.0007163545,0.00005562102,0.003501284,0.9808304,0.0001979941,0.004872804,0.00001586137],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937543,0.002337655,0.00135585,0.0001697649,0.00007116522,0.00003943381,0.0002877141,0.0001140835,0.001870015],"genre_scores_gemma":[0.994032,0.001862991,0.001446662,0.00009035222,0.00002902115,0.00005659201,0.0004057669,0.00002131075,0.002055173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001447429,"threshold_uncertainty_score":0.004842162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01127324377598136,"score_gpt":0.2230165687000897,"score_spread":0.2117433249241084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}