{"id":"W1581604096","doi":"10.1016/s0065-3233(01)56009-x","title":"Pure selective estrogen receptor modulators, new molecules having absolute cell specificity ranging from pure antiestrogenic to complete estrogen-like activities","year":2001,"lang":"en","type":"review","venue":"Advances in protein chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"","keywords":"Antiestrogen; Raloxifene; Tamoxifen; Estrogen receptor; Selective estrogen receptor modulator; Estrogen; Estrogen receptor alpha; Cancer research; Biology; Estrogen receptor beta; Chemistry; Internal medicine; Endocrinology; Cell biology; Pharmacology; Breast cancer; Cancer; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0002137076,0.001439138,0.001917545,0.0001537405,0.0002302218,0.0001308663,0.001150974,0.001478055,0.00006890231],"category_scores_gemma":[0.00009676177,0.001456723,0.0009048407,0.0007492073,0.000184367,0.00005003733,0.0005131048,0.001447386,0.00005051308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003611192,"about_ca_system_score_gemma":0.0007115532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006402667,"about_ca_topic_score_gemma":0.00001009813,"domain_scores_codex":[0.994948,0.0002289273,0.001046668,0.002008355,0.000499161,0.00126891],"domain_scores_gemma":[0.9973957,0.00007512756,0.0007323332,0.001211495,0.00008570876,0.000499667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004752936,0.0004489951,0.0001108197,0.00794139,0.001169357,0.0003456289,0.0001491868,0.0008765247,0.6513779,0.00002646763,0.001729804,0.3353487],"study_design_scores_gemma":[0.0007379494,0.000153867,6.254395e-7,0.00437307,0.0002720947,0.0001054197,0.000092918,0.00001347852,0.3154174,0.0000853177,0.6772974,0.001450399],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.06303884,0.9329467,0.0005544377,0.00001637728,0.0003102933,0.001992429,0.0004504753,0.00009803117,0.0005923487],"genre_scores_gemma":[0.00330598,0.9844718,0.006168618,0.00003566384,0.001333973,0.0005613525,0.002240505,0.000323843,0.001558291],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6755676,"threshold_uncertainty_score":0.9998358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01015925376498575,"score_gpt":0.2637256604570781,"score_spread":0.2535664066920923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}