{"id":"W1581907039","doi":"10.1038/86278","title":"CTLA-4 up-regulation plays a role in tolerance mediated by CD45","year":2001,"lang":"en","type":"letter","venue":"Nature Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Cell biology; Biology; Computational biology; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity","insufficient_payload"],"category_scores_codex":[0.0003465587,0.001179434,0.001798567,0.0009685116,0.0002884131,0.00003872537,0.001550479,0.01929818,0.003742586],"category_scores_gemma":[0.0002464488,0.001142441,0.000352303,0.0008074772,0.0009501822,0.0001986649,0.0003471937,0.01675795,0.003743601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003776618,"about_ca_system_score_gemma":0.0002546965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000477074,"about_ca_topic_score_gemma":0.0001478263,"domain_scores_codex":[0.9938765,0.001164466,0.001260404,0.001571599,0.0001453607,0.001981634],"domain_scores_gemma":[0.9968807,0.0007791981,0.0007534034,0.001330705,0.0002290486,0.0000269864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002890439,0.0001113703,0.0001581704,0.00002285883,0.0003535683,0.0001243504,0.000135754,0.000001781824,0.5133255,0.00004911092,0.4841172,0.001311302],"study_design_scores_gemma":[0.004217533,0.0002997117,0.00037982,0.0001146059,0.00009284437,0.0007146795,0.00005345677,0.000006301056,0.0793228,0.0006404926,0.9131566,0.001001138],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1340169,0.4610661,0.00005084001,0.3600138,0.02606758,0.002430788,0.001101471,0.001101013,0.01415151],"genre_scores_gemma":[0.4904243,0.005809035,0.00005508579,0.348479,0.001886967,0.0005174484,0.04111451,0.0004396754,0.111274],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.4552571,"threshold_uncertainty_score":0.9991026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004250834155664068,"score_gpt":0.2059624812308354,"score_spread":0.2017116470751713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}