{"id":"W1581940992","doi":"10.1111/j.1476-5381.2011.01403.x","title":"Behind the curtain: cellular mechanisms for allosteric modulation of calcium‐sensing receptors","year":2011,"lang":"en","type":"review","venue":"British Journal of Pharmacology","topic":"Biochemical Analysis and Sensing Techniques","field":"Nursing","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Royal Victoria Hospital","funders":"National Institute of General Medical Sciences; National Institutes of Health","keywords":"Allosteric regulation; Allosteric modulator; Calcium-sensing receptor; Receptor; Cell biology; Intracellular; Chemistry; Endoplasmic reticulum; Agonist; Allosteric enzyme; Calcium signaling; Biophysics; Biology; Biochemistry; Calcium; Calcium metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001273704,0.0004756369,0.001150061,0.0003413346,0.0006033332,0.002244537,0.0007793126,0.001710733,0.005755584],"category_scores_gemma":[0.001206218,0.0002779875,0.0006696912,0.0002760363,0.002354389,0.003582927,0.001477811,0.00433261,0.002575552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001017391,"about_ca_system_score_gemma":0.0005653608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003888797,"about_ca_topic_score_gemma":0.0004207516,"domain_scores_codex":[0.9992878,0.000139725,0.00004231346,0.0001589564,0.0002222639,0.0001489323],"domain_scores_gemma":[0.9995491,0.0001422619,0.00005593908,0.00009257717,0.00008081095,0.00007931802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001071234,0.0001441573,0.001317867,0.002065864,0.000160792,0.001755109,0.001000579,0.001423176,0.58935,0.2084759,0.03000415,0.1632311],"study_design_scores_gemma":[0.0003269615,0.001211627,0.007509355,0.0006601102,0.0001932434,0.003492964,0.001567937,0.007499347,0.2627676,0.1609674,0.5535909,0.0002124935],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2101914,0.3973333,0.1224173,0.1913027,0.01436962,0.0002097491,0.001025162,0.002819911,0.0603309],"genre_scores_gemma":[0.7884431,0.1372905,0.01174235,0.02799539,0.003926763,0.0001644647,0.0003218975,0.0003136205,0.02980193],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005755584,"threshold_uncertainty_score":0.01925433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06929211451260187,"score_gpt":0.3510204091450196,"score_spread":0.2817282946324178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}