{"id":"W1582127042","doi":"10.1139/y06-020","title":"Altered glucose homeostasis in mice lacking the receptor protein tyrosine phosphatase sigmaThis paper is one of a selection of papers published in this Special issue, entitled Second Messengers and Phosphoproteins—12th International Conference.","year":2006,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université Laval; Centre hospitalier de l'Université Laval; Centre Hospitalier Universitaire Sainte-Justine; McGill University Health Centre","funders":"","keywords":"Insulin; Internal medicine; Insulin receptor; Endocrinology; Phosphorylation; Glucose homeostasis; Tyrosine phosphorylation; Protein tyrosine phosphatase; Biology; Insulin receptor substrate; Knockout mouse; Protein kinase B; Tyrosine; Phosphatase; Homeostasis; Receptor; Insulin resistance; Cell biology; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002222054,0.001617198,0.0006126355,0.001168985,0.0002979113,0.0008201603,0.0005800652,0.001054113,0.006421214],"category_scores_gemma":[0.0001802231,0.0005925425,0.0007316187,0.0004840871,0.0005068093,0.0004659265,0.0004366566,0.001695565,0.001228303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003374681,"about_ca_system_score_gemma":0.0002335637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003781412,"about_ca_topic_score_gemma":0.0005782191,"domain_scores_codex":[0.9996819,0.00002459095,0.00005464817,0.0001215184,0.00006975849,0.00004758999],"domain_scores_gemma":[0.9993543,0.00005785252,0.0003118088,0.00004856965,0.00003453682,0.0001929313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003558442,0.00006148298,0.0004764493,0.00004395433,0.00002168092,0.0003193416,0.0000199583,0.00004728211,0.9970144,0.000169671,0.00009642514,0.001373575],"study_design_scores_gemma":[0.0003127157,0.001793638,0.03988587,0.0001219452,0.000323099,0.005371658,0.0002504492,0.002158282,0.9402512,0.0005779219,0.00888459,0.0000686236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820039,0.001660876,0.008833285,0.0004203714,0.000333989,0.00006381092,0.004408449,0.0006346406,0.001640766],"genre_scores_gemma":[0.9545934,0.003971235,0.00901826,0.0004188504,0.000143364,0.0002717724,0.00749559,0.0007141528,0.02337337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006421214,"threshold_uncertainty_score":0.0214811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007655707982190776,"score_gpt":0.2325729525389278,"score_spread":0.224917244556737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}