{"id":"W1582334521","doi":"10.1002/9783527610419.ntls0015","title":"<scp>DNA</scp> –Chitosan Nanoparticles for Gene Therapy: Current Knowledge and Future Trends","year":2003,"lang":"en","type":"other","venue":"Nanotechnologies for the Life Sciences","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital du Sacré-Cœur de Montréal","funders":"","keywords":"Chitosan; Coacervate; Transfection; Nanoparticle; Emulsion; DNA; Materials science; Surface modification; Gene delivery; Solubility; Chemistry; Nanotechnology; Biochemistry; Gene; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008455334,0.0004105298,0.0004418906,0.0005494378,0.0001589972,0.0009594539,0.000539174,0.0009790452,0.007488175],"category_scores_gemma":[0.0002464917,0.0001573495,0.0002758048,0.0005865177,0.0004622664,0.001043296,0.0002740758,0.0006477723,0.002107993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005628558,"about_ca_system_score_gemma":0.0008591589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009412245,"about_ca_topic_score_gemma":0.001515636,"domain_scores_codex":[0.9998859,0.00002021309,0.00001065443,0.00001902742,0.00004307568,0.00002114618],"domain_scores_gemma":[0.9997994,0.00009392387,0.00002154831,0.000007109527,0.00004632776,0.00003156075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006639223,0.0003998572,0.001030338,0.005810552,0.00008735195,0.0005897232,0.0001828396,0.001780639,0.1514005,0.01083681,0.02535935,0.8018582],"study_design_scores_gemma":[0.0001646735,0.0009226567,0.003213366,0.001104253,0.000186111,0.002557869,0.0002843507,0.003250174,0.1222245,0.008057611,0.8579615,0.00007293085],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01536873,0.937681,0.01510068,0.007369381,0.001013402,0.00006226887,0.0001656631,0.000211934,0.02302699],"genre_scores_gemma":[0.07685604,0.8612433,0.01548719,0.003043505,0.00205366,0.0001535101,0.0005689653,0.00007106466,0.04052285],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007488175,"threshold_uncertainty_score":0.0250504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0291525366658948,"score_gpt":0.2940446358250672,"score_spread":0.2648920991591724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}