{"id":"W1582362120","doi":"10.1111/j.1462-5822.2011.01716.x","title":"The Type VI secretion system of Burkholderia cenocepacia affects multiple Rho family GTPases disrupting the actin cytoskeleton and the assembly of NADPH oxidase complex in macrophages","year":2011,"lang":"en","type":"article","venue":"Cellular Microbiology","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Canada","keywords":"Biology; Cell biology; Burkholderia cenocepacia; RHOA; GTPase; Membrane ruffling; Rac GTP-Binding Proteins; Actin cytoskeleton; CDC42; RAC1; NADPH oxidase; Secretion; Cytoskeleton; Type VI secretion system; Microbiology; Biochemistry; Signal transduction; Reactive oxygen species; Cell; Virulence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001121988,0.0002689848,0.0001430086,0.0001076054,0.0001144449,0.0002016686,0.0001278569,0.0002982114,0.0006783996],"category_scores_gemma":[0.0001293878,0.0001092378,0.0002825449,0.00008001403,0.0001650164,0.0001232162,0.0001359986,0.0003890251,0.0001793918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002377799,"about_ca_system_score_gemma":0.0001442998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006795805,"about_ca_topic_score_gemma":0.0005812107,"domain_scores_codex":[0.9998612,0.00003788008,0.00001901661,0.0000185874,0.00003094369,0.00003221694],"domain_scores_gemma":[0.9999241,0.00001310844,0.00002275163,0.00001088014,0.000008439348,0.00002072093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000581254,0.0000196962,0.0001454969,0.000009580548,0.000002285911,0.00005094841,0.000004976308,0.00001844123,0.9994966,0.00002500593,0.000006151669,0.0001625959],"study_design_scores_gemma":[0.00001894946,0.0004323755,0.003908289,0.000003564262,0.00001071693,0.0003941099,0.00002880451,0.0003245902,0.994417,0.00003474712,0.0004244556,0.000002405781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987285,0.000353359,0.0005018799,0.00004996087,0.00001311606,0.000007578612,0.00008336176,0.000009740239,0.0002525309],"genre_scores_gemma":[0.9984888,0.0002267904,0.0005266241,0.0000212957,0.000003314662,0.000009406883,0.0001307181,0.000004842539,0.0005881338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006795805,"threshold_uncertainty_score":0.002269447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02029962052070737,"score_gpt":0.2418387767160841,"score_spread":0.2215391561953767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}