{"id":"W1582362120","doi":"10.1111/j.1462-5822.2011.01716.x","title":"The Type VI secretion system of Burkholderia cenocepacia affects multiple Rho family GTPases disrupting the actin cytoskeleton and the assembly of NADPH oxidase complex in macrophages","year":2011,"lang":"en","type":"article","venue":"Cellular Microbiology","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Canada","keywords":"Biology; Cell biology; Burkholderia cenocepacia; RHOA; GTPase; Membrane ruffling; Rac GTP-Binding Proteins; Actin cytoskeleton; CDC42; RAC1; NADPH oxidase; Secretion; Cytoskeleton; Type VI secretion system; Microbiology; Biochemistry; Signal transduction; Reactive oxygen species; Cell; Virulence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007723471,0.0001834574,0.00031282,0.0000336753,0.0002049214,0.00001543454,0.0003411851,0.0001370026,0.000003746153],"category_scores_gemma":[0.0003156973,0.00009600946,0.0000857087,0.0001176873,0.0009525703,0.000004094766,0.000381288,0.0001356944,0.000001987867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001863606,"about_ca_system_score_gemma":0.00004484462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003421825,"about_ca_topic_score_gemma":0.0002067837,"domain_scores_codex":[0.9983081,0.0007266141,0.0003029534,0.000276322,0.00005361709,0.0003324345],"domain_scores_gemma":[0.9989372,0.0002575614,0.0002484321,0.0004096455,0.0001175152,0.00002968586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006218317,0.00002755715,0.001246611,0.0001130293,0.00009801089,0.000004380834,0.0003672688,0.000001510361,0.9971167,0.000103697,0.0001091888,0.0001901431],"study_design_scores_gemma":[0.001181879,0.000285254,0.009769944,0.00004406678,0.00002655453,0.00002291683,0.001642759,0.00008042392,0.9856105,0.000007160683,0.001216581,0.0001119166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954113,0.003572682,0.0000606501,0.00008941437,0.000135075,0.0005352777,0.00004418738,0.000006981982,0.0001444365],"genre_scores_gemma":[0.9991595,0.0005161864,0.00008296836,0.00002682298,0.00005114465,0.00002585673,0.00007616991,0.00001813962,0.00004327499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01150623,"threshold_uncertainty_score":0.3915152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02029962052070737,"score_gpt":0.2418387767160841,"score_spread":0.2215391561953767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}