{"id":"W1582771675","doi":"10.1038/sj.bjp.0707334","title":"Differential regulation of Akt, caspases and MAP kinases underlies smooth muscle cell apoptosis during aortic remodelling in SHR treated with amlodipine","year":2007,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Amlodipine; Protein kinase B; Apoptosis; Kinase; p38 mitogen-activated protein kinases; Endocrinology; Phosphorylation; Internal medicine; Mitogen-activated protein kinase; Muscle hypertrophy; Medicine; Caspase 3; Pharmacology; Biology; Protein kinase A; Programmed cell death; Cell biology; Biochemistry; Blood pressure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000125389,0.0002592284,0.000481389,0.0002486766,0.0001475254,0.0001887976,0.0001145621,0.0002316553,0.00093943],"category_scores_gemma":[0.0001191854,0.0001654745,0.0003510015,0.0001061255,0.0002240901,0.0002076636,0.0001702165,0.0006917178,0.0001669736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002047527,"about_ca_system_score_gemma":0.0001155587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003971807,"about_ca_topic_score_gemma":0.000871276,"domain_scores_codex":[0.9998767,0.00001734442,0.00001051856,0.00002599533,0.00002889818,0.00004056683],"domain_scores_gemma":[0.9998865,0.000008204545,0.00003773112,0.00001005677,0.00001521892,0.00004215719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001404281,0.00005967601,0.001393939,0.00003063754,0.00001088559,0.00007666324,0.00003351607,0.00001649487,0.995869,0.00002029503,0.00002014693,0.001064335],"study_design_scores_gemma":[0.0001528979,0.003101984,0.1716415,0.0000138991,0.0001283796,0.0004999405,0.0001956854,0.001105865,0.8220796,0.0001176091,0.0009470598,0.00001558117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986079,0.0006618362,0.000339701,0.00003439396,0.0000120083,0.00001012404,0.00009820884,0.00001921017,0.0002164896],"genre_scores_gemma":[0.9978878,0.000459066,0.0004476786,0.00002871579,0.00001398269,0.00003450009,0.0001838592,0.000005140966,0.0009391714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00093943,"threshold_uncertainty_score":0.003142715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006677511235702862,"score_gpt":0.2301996137101059,"score_spread":0.2235221024744031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}