{"id":"W1582839030","doi":"10.1038/sj.ijo.0802911","title":"Lessons from human mutations in PPARγ","year":2005,"lang":"en","type":"article","venue":"International Journal of Obesity","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":false,"ca_institutions":"Robarts Clinical Trials","funders":"Canada Research Chairs; Canadian Diabetes Association","keywords":"LMNA; Lipodystrophy; Endocrinology; Insulin resistance; Internal medicine; Biology; Adipose tissue; Mutation; Medicine; Genetics; Insulin; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000768407,0.00004353657,0.00005684287,0.00005671319,0.00002092691,0.00001670428,0.0001571765,0.00004634355,0.0001083726],"category_scores_gemma":[0.00003248721,0.00004104888,0.00005523357,0.00002142841,0.00001791914,0.000009416064,0.00002806641,0.00008601067,0.000008797168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002936994,"about_ca_system_score_gemma":0.00002567671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003878302,"about_ca_topic_score_gemma":0.0002481296,"domain_scores_codex":[0.9995599,0.00001878746,0.0001754924,0.00006781094,0.0001281732,0.00004982718],"domain_scores_gemma":[0.9996749,0.000005688444,0.0001082195,0.00005594751,0.0001285259,0.00002677074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001706943,0.0002998673,0.1172614,0.000001297498,0.0002056892,0.0000416107,0.0002493939,0.001149648,0.8493531,0.001290853,0.00602976,0.02394677],"study_design_scores_gemma":[0.001415896,0.0001445801,0.8178838,0.00002557782,0.00002179899,0.00009411458,0.00009742232,0.00007572291,0.08757793,0.003135513,0.08939069,0.0001369048],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967425,0.00008786674,0.0008330178,0.001018014,0.0003297988,0.00001536697,0.00001097925,0.000001531146,0.0009609624],"genre_scores_gemma":[0.9972497,0.00002464413,0.001407054,0.0002097131,0.0009520128,2.922723e-7,0.00003419988,0.000004373034,0.0001180162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7617751,"threshold_uncertainty_score":0.1673925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01117484492643907,"score_gpt":0.3009987980632153,"score_spread":0.2898239531367762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}