{"id":"W1583000270","doi":"10.1186/ar1350","title":"A proinflammatory chemokine, CCL3, sensitizes the heat-gated and capsaicin-gated ion channel, TRPV1","year":2004,"lang":"en","type":"article","venue":"Arthritis Research","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Arthritis Network; School of Medicine, University of California, San Diego; Menzies Institute for Medical Research; National Cancer Institute; Arthritis Society; University of North Carolina at Chapel Hill; Genentech; National Institutes of Health; Biogen; Lupus Research Institute; Pfizer; Natural Sciences and Engineering Research Council of Canada; Dutch Arthritis Association; Oesterreichische Nationalbank; Deutsche Forschungsgemeinschaft; Nuffield Foundation; Physiotherapy Foundation of Canada; Canadian Institutes of Health Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Lupus Research Alliance; Wellcome Trust; Newcastle University; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; Austrian Science Fund; Arthritis Foundation","keywords":"TRPV1; CCR1; Chemokine receptor; Chemokine; Sensitization; Chemistry; Pertussis toxin; Cell biology; CCL3; Hyperalgesia; Receptor; Pharmacology; Biology; Immunology; Transient receptor potential channel; Biochemistry; G protein; Nociception; CCL2","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001096158,0.0001926686,0.0003039486,0.0001946952,0.000481298,0.0000678678,0.00009037132,0.0001291705,0.0000621431],"category_scores_gemma":[0.0002368609,0.0001339926,0.00006250091,0.0004424497,0.0003038595,0.00009839379,0.0001033262,0.0004978103,0.0001505605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001326731,"about_ca_system_score_gemma":0.0002410579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009703723,"about_ca_topic_score_gemma":0.0003229583,"domain_scores_codex":[0.9977329,0.0002102962,0.000243842,0.0004174817,0.0007269505,0.0006684893],"domain_scores_gemma":[0.9988484,0.0001206807,0.00002573526,0.0004149367,0.0003115799,0.0002786746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002950564,0.00301969,0.004310361,0.000758532,0.001320919,0.02104053,0.012498,0.0001035727,0.6824358,0.01228195,0.01158176,0.2476983],"study_design_scores_gemma":[0.04094805,0.004917226,0.04265803,0.003379151,0.0001103318,0.004632561,0.003892404,0.001728929,0.8616258,0.01469512,0.02053632,0.000876079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865803,0.002865566,0.00003149997,0.006805309,0.00008597301,0.001318199,0.00001269236,0.0001125355,0.002187989],"genre_scores_gemma":[0.9961544,0.002363818,0.0002203861,0.0002745252,0.0002138948,0.00006264526,0.00004732967,0.00004068246,0.0006222731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2468222,"threshold_uncertainty_score":0.5464061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03492123425285889,"score_gpt":0.3219303679735671,"score_spread":0.2870091337207082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}