{"id":"W1583000270","doi":"10.1186/ar1350","title":"A proinflammatory chemokine, CCL3, sensitizes the heat-gated and capsaicin-gated ion channel, TRPV1","year":2004,"lang":"en","type":"article","venue":"Arthritis Research","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Arthritis Network; School of Medicine, University of California, San Diego; Menzies Institute for Medical Research; National Cancer Institute; Arthritis Society; University of North Carolina at Chapel Hill; Genentech; National Institutes of Health; Biogen; Lupus Research Institute; Pfizer; Natural Sciences and Engineering Research Council of Canada; Dutch Arthritis Association; Oesterreichische Nationalbank; Deutsche Forschungsgemeinschaft; Nuffield Foundation; Physiotherapy Foundation of Canada; Canadian Institutes of Health Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Lupus Research Alliance; Wellcome Trust; Newcastle University; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; Austrian Science Fund; Arthritis Foundation","keywords":"TRPV1; CCR1; Chemokine receptor; Chemokine; Sensitization; Chemistry; Pertussis toxin; Cell biology; CCL3; Hyperalgesia; Receptor; Pharmacology; Biology; Immunology; Transient receptor potential channel; Biochemistry; G protein; Nociception; CCL2","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001664629,0.000429946,0.0004745746,0.0008619677,0.0002983203,0.001136606,0.0004666892,0.000560866,0.004279477],"category_scores_gemma":[0.0015058,0.000128795,0.0005882706,0.0004771515,0.0007428242,0.00051679,0.0005464174,0.0004876549,0.0006071927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007294817,"about_ca_system_score_gemma":0.0006059671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008808546,"about_ca_topic_score_gemma":0.0007392893,"domain_scores_codex":[0.9986358,0.0004738044,0.0001466781,0.0001946731,0.0003512222,0.0001978102],"domain_scores_gemma":[0.9986111,0.0004213159,0.0005315124,0.00006721219,0.0002398428,0.0001289491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001811195,0.0003409047,0.02185475,0.006896568,0.0001600957,0.001458571,0.0003048099,0.001174215,0.8391207,0.002560372,0.00992584,0.1143919],"study_design_scores_gemma":[0.0003311535,0.006956642,0.1261207,0.002054544,0.0005618416,0.01294245,0.0007051197,0.003276704,0.6726774,0.00337482,0.1708065,0.000192087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5846109,0.3372655,0.03486381,0.01077079,0.003273851,0.001069585,0.006574179,0.001346072,0.02022534],"genre_scores_gemma":[0.9412639,0.04199761,0.007066211,0.002375635,0.001194218,0.0004247175,0.001728538,0.00005608051,0.003893191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004279477,"threshold_uncertainty_score":0.01431626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03492123425285889,"score_gpt":0.3219303679735671,"score_spread":0.2870091337207082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}