{"id":"W1583217239","doi":"10.1016/b978-0-12-407865-9.00007-8","title":"Quantification of Receptor Tyrosine Kinase Activation and Transactivation by G-Protein-Coupled Receptors Using Spatial Intensity Distribution Analysis (SpIDA)","year":2013,"lang":"en","type":"article","venue":"Methods in enzymology on CD-ROM/Methods in enzymology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université Laval","funders":"","keywords":"Biophysics; Receptor; Chemistry; Förster resonance energy transfer; Receptor tyrosine kinase; Transactivation; Confocal microscopy; Biological system; Fluorescence; Biochemistry; Biology; Cell biology; Physics; Optics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008331577,0.0005332222,0.0004457949,0.001272492,0.0004436019,0.0007125665,0.0006909753,0.0005088756,0.002417713],"category_scores_gemma":[0.0006078129,0.0003458741,0.0005761426,0.001260249,0.0005271065,0.0008035409,0.0005019261,0.001345494,0.0006152599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006923371,"about_ca_system_score_gemma":0.0004836453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001134477,"about_ca_topic_score_gemma":0.001523511,"domain_scores_codex":[0.9993681,0.0000962476,0.00003670836,0.0001417036,0.0002420784,0.0001151177],"domain_scores_gemma":[0.9993493,0.0002275004,0.0001057176,0.00009421219,0.0001758506,0.00004750746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001727951,0.0000668234,0.001406088,0.0001400276,0.00004514013,0.00003376268,0.00007986007,0.0008275707,0.9805848,0.001410325,0.0003144062,0.01491844],"study_design_scores_gemma":[0.00001346763,0.0000745396,0.007070427,0.000007010836,0.00003728737,0.0001340071,0.00006216154,0.02385456,0.9668882,0.0004675638,0.0013635,0.00002722415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.6144515,0.001241247,0.3717588,0.0002039056,0.00007442127,0.0001323523,0.001467621,0.001492037,0.009178085],"genre_scores_gemma":[0.7616138,0.001481074,0.2299142,0.0001402584,0.00003543032,0.0006491474,0.0009330626,0.000240357,0.004992682],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002417713,"threshold_uncertainty_score":0.008088052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03091090795334875,"score_gpt":0.3505639569209983,"score_spread":0.3196530489676496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}