{"id":"W1583282648","doi":"10.1111/j.1471-4159.2004.02486.x","title":"CHIP promotes proteasomal degradation of familial ALS‐linked mutant SOD1 by ubiquitinating Hsp/Hsc70","year":2004,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":182,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"RIKEN Brain Science Institute","keywords":"SOD1; Mutant; Ubiquitin; Proteasome; Hsp70; Cell biology; Biology; Lactacystin; Superoxide dismutase; Molecular biology; Heat shock; Chemistry; Heat shock protein; Biochemistry; Proteasome inhibitor; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001407949,0.0003711404,0.0001910661,0.0002069804,0.000123966,0.0001740035,0.0001246495,0.0001439501,0.001002285],"category_scores_gemma":[0.00007633551,0.0001499675,0.0002155596,0.00008767071,0.0001678679,0.00009360753,0.0001895088,0.0002981608,0.0002556067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002011696,"about_ca_system_score_gemma":0.0001182169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004546421,"about_ca_topic_score_gemma":0.0008757276,"domain_scores_codex":[0.9998935,0.00001897396,0.000011361,0.0000229348,0.00002402907,0.00002911852],"domain_scores_gemma":[0.9999067,0.00001487845,0.00002349431,0.00001003749,0.00001094673,0.00003396992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006126369,0.00001966635,0.0001646788,0.00003184244,0.000006875031,0.00003272021,0.000009767467,0.00002393081,0.9990591,0.00002303674,0.00003802194,0.0005290866],"study_design_scores_gemma":[0.00001195568,0.0001829704,0.01128263,0.000007414607,0.00002022213,0.0002496384,0.00002447081,0.0009838575,0.9858183,0.00002873503,0.001385926,0.000003828024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971164,0.001049221,0.001092569,0.00004487468,0.00001881458,0.00001030783,0.000160735,0.00007581668,0.000431289],"genre_scores_gemma":[0.9962274,0.0004913062,0.0009172141,0.00005245109,0.000007818913,0.000021424,0.0004781845,0.00001773279,0.001786479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001002285,"threshold_uncertainty_score":0.00335294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02159893110994066,"score_gpt":0.285710063870882,"score_spread":0.2641111327609414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}