{"id":"W15836969","doi":"10.1096/fasebj.23.1_supplement.lb198","title":"Successful inhibition of Dnmt1 expression in bovine using RNA interference.","year":2009,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Consejo Nacional de Ciencia y Tecnología","keywords":"RNA interference; Reprogramming; DNMT1; Biology; Gene knockdown; Epigenetics; DNA methylation; Methylation; Molecular biology; Gene expression; Gene silencing; Small hairpin RNA; Cell biology; Gene; RNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005588444,0.0005407084,0.0004745728,0.0003632267,0.0002903803,0.0004579808,0.0004438304,0.0006679677,0.002095703],"category_scores_gemma":[0.0004099503,0.0003350031,0.0004347596,0.0002470257,0.0003302088,0.0002244643,0.0003216269,0.0006877469,0.001256761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006936534,"about_ca_system_score_gemma":0.0003369472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002882574,"about_ca_topic_score_gemma":0.004210826,"domain_scores_codex":[0.9994784,0.00005700082,0.0000495509,0.0001983428,0.0001120578,0.0001046685],"domain_scores_gemma":[0.9996586,0.0001007753,0.0001052527,0.00005829699,0.00003892152,0.00003817763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003934021,0.000005956295,0.00005212282,0.00004214446,0.000004665592,0.00002560194,0.00001874014,0.00002477235,0.9983186,0.00008885309,0.00006071981,0.001318519],"study_design_scores_gemma":[0.00001383003,0.0001387374,0.001608068,0.00001573451,0.00003324148,0.0002724937,0.0000157881,0.0005955091,0.9847569,0.00004012741,0.0125026,0.000006958357],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8786467,0.02310833,0.06900149,0.001111855,0.0005344507,0.0004817762,0.009695583,0.001959348,0.01546031],"genre_scores_gemma":[0.921075,0.005508885,0.04076758,0.0003495916,0.00005333081,0.0002514073,0.007150563,0.0005162694,0.02432731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002882574,"threshold_uncertainty_score":0.007010818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01688869033342971,"score_gpt":0.2629042334301287,"score_spread":0.246015543096699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}