{"id":"W1583708762","doi":"10.4049/jimmunol.180.2.683","title":"Cutting Edge: Cooperation of IPS-1- and TRIF-Dependent Pathways in Poly IC-Enhanced Antibody Production and Cytotoxic T Cell Responses","year":2008,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":150,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"","keywords":"TRIF; TLR3; RNA Helicase A; Adjuvant; Chemistry; Signal transducing adaptor protein; Cell biology; Immune system; Signal transduction; RNA; Biology; Molecular biology; Helicase; Toll-like receptor; Gene; Immunology; Innate immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008195891,0.0001228174,0.0003021875,0.0002808267,0.0002015503,0.000005668322,0.0001075825,0.0001603973,0.00006827094],"category_scores_gemma":[0.0003833246,0.000088387,0.0000392501,0.0001262448,0.0003059832,0.0002279552,0.00004862964,0.0005203065,0.00001181139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003902381,"about_ca_system_score_gemma":0.00008589772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004413772,"about_ca_topic_score_gemma":0.000006866501,"domain_scores_codex":[0.9983593,0.0007189857,0.0005984399,0.0001179955,0.00003687704,0.0001684393],"domain_scores_gemma":[0.9988937,0.0002181351,0.0005349642,0.0001499779,0.000194409,0.000008823391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003086597,0.0001235495,0.0009942522,0.0000105963,0.00006614199,0.000004129516,0.002793821,0.000008925758,0.9910927,0.00002579415,0.0001271964,0.001666268],"study_design_scores_gemma":[0.001529127,0.001040726,0.02908247,0.00006374386,0.00003404545,0.002999149,0.002010987,0.000003747077,0.9627537,0.00001774805,0.0003821412,0.00008245531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833258,0.0141898,0.000339217,0.0002621062,0.001587893,0.0001452146,0.000001099735,0.000008477541,0.0001403838],"genre_scores_gemma":[0.992426,0.005941044,0.00003188344,0.00004298161,0.00003480867,0.000001844219,0.000004659985,0.000009292525,0.00150747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02833906,"threshold_uncertainty_score":0.3604317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01577589976241302,"score_gpt":0.2417453286206265,"score_spread":0.2259694288582135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}