{"id":"W1583708762","doi":"10.4049/jimmunol.180.2.683","title":"Cutting Edge: Cooperation of IPS-1- and TRIF-Dependent Pathways in Poly IC-Enhanced Antibody Production and Cytotoxic T Cell Responses","year":2008,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":150,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"","keywords":"TRIF; TLR3; RNA Helicase A; Adjuvant; Chemistry; Signal transducing adaptor protein; Cell biology; Immune system; Signal transduction; RNA; Biology; Molecular biology; Helicase; Toll-like receptor; Gene; Immunology; Innate immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003264171,0.0008055811,0.0003597452,0.0002413874,0.0001161766,0.0004518946,0.0003061053,0.0005321535,0.001978372],"category_scores_gemma":[0.0001678133,0.000190456,0.0003218471,0.0001050642,0.0003032283,0.0004658315,0.000375585,0.0009919315,0.0008367968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002665693,"about_ca_system_score_gemma":0.0002459365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007403345,"about_ca_topic_score_gemma":0.00009652839,"domain_scores_codex":[0.999656,0.0000531515,0.00004010766,0.00005717091,0.0001051483,0.00008847781],"domain_scores_gemma":[0.9997068,0.00003665928,0.00009986032,0.00003348681,0.00003653374,0.00008653439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003264582,0.00002782301,0.00035447,0.0001137609,0.000005392471,0.000122774,0.000008458908,0.00008327873,0.9945825,0.0004457893,0.00009637221,0.003833003],"study_design_scores_gemma":[0.00003776277,0.000250648,0.004801838,0.00002269264,0.00003090257,0.000891536,0.00002004166,0.001500382,0.9902557,0.0002301903,0.001954057,0.000004246428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804936,0.003990542,0.009703531,0.0004522273,0.00007830718,0.00004366522,0.0005221969,0.000257043,0.004458931],"genre_scores_gemma":[0.9891018,0.001192865,0.005547977,0.0002247702,0.00005289556,0.00004434154,0.0006111406,0.0000403558,0.003183859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001978372,"threshold_uncertainty_score":0.006618321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01577589976241302,"score_gpt":0.2417453286206265,"score_spread":0.2259694288582135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}