{"id":"W1584263495","doi":"","title":"Solubility Enhancement of Poorly Water Soluble Drug Celecoxib","year":2013,"lang":"en","type":"article","venue":"Pharmatutor","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal College of Physicians and Surgeons of Canada","funders":"","keywords":"Solubility; Bioavailability; Dissolution; Drug; Water soluble; Pharmacology; Chemistry; Dispersion (optics); Amorphous solid; Absorption (acoustics); Dosage form; Chromatography; Materials science; Chemical engineering; Medicine; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001157713,0.0003118477,0.0004866471,0.0001044548,0.0002460326,0.0000445002,0.0004827331,0.0002040683,0.02374557],"category_scores_gemma":[0.00003091703,0.0002488473,0.0002100338,0.0001366359,0.0002532877,0.0005031737,0.0002014222,0.0005765645,0.006076116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009648132,"about_ca_system_score_gemma":0.0000739946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004937464,"about_ca_topic_score_gemma":0.00001226866,"domain_scores_codex":[0.997084,0.0005382199,0.0008081807,0.0004327937,0.0003109337,0.0008258576],"domain_scores_gemma":[0.9985753,0.0002042404,0.0001896957,0.0003940921,0.000286095,0.0003506073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002825742,0.001474982,0.004735982,0.0005222126,0.000366768,0.00001104316,0.004256223,0.00008440862,0.7531587,0.0003367388,0.2281686,0.006601801],"study_design_scores_gemma":[0.001350751,0.00005936008,0.0003433161,0.00001291466,0.00007814019,0.00000736445,0.0001780269,0.00206583,0.7105349,0.000371287,0.2847187,0.0002794762],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9742267,0.0006346687,0.0001539567,0.001565027,0.004385911,0.001156994,0.00003865137,0.000158189,0.01767997],"genre_scores_gemma":[0.9830555,0.00009002655,0.0001703019,0.001794077,0.0003204006,0.0002545634,0.00004450955,0.0000288813,0.01424171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05655009,"threshold_uncertainty_score":0.9999964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07915581229675091,"score_gpt":0.3833962123686496,"score_spread":0.3042404000718987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}