{"id":"W1584527630","doi":"10.1002/path.4404","title":"Up‐regulation of the interferon‐related genes in <i><scp>BRCA2</scp></i> knockout epithelial cells","year":2014,"lang":"en","type":"article","venue":"The Journal of Pathology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; National Institute for Health and Care Research; Canadian Cancer Society; Cancer Research UK; Wellcome Trust","keywords":"Biology; BRCA2 Protein; Interferon; DNA damage; Cancer research; Knockout mouse; Gene; IRF1; Homologous recombination; RAD51; Molecular biology; Gene expression; Mutation; Genetics; DNA; Germline mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001045485,0.0003491812,0.0002984489,0.0002831009,0.0001601104,0.000338141,0.0001329016,0.0003056644,0.002054132],"category_scores_gemma":[0.00008954783,0.0001832019,0.0003104527,0.000264584,0.0002767195,0.0001390615,0.0001509491,0.0006995181,0.0007165939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002575257,"about_ca_system_score_gemma":0.0001746357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00114075,"about_ca_topic_score_gemma":0.001186054,"domain_scores_codex":[0.9997967,0.0000195672,0.00002634315,0.00005797099,0.00005827825,0.0000412269],"domain_scores_gemma":[0.999778,0.00003290001,0.00006631695,0.0000344264,0.00002285479,0.00006553652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002928553,0.000006566414,0.000107628,0.00001249116,0.000002203483,0.00003424652,0.000007795363,0.0000166609,0.9995639,0.00001923285,0.00002554076,0.0001745261],"study_design_scores_gemma":[0.000008355981,0.00007648004,0.01097121,0.000006242324,0.00001258353,0.0003952307,0.00004349211,0.000634819,0.9857099,0.0000273405,0.00210909,0.000005343673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989328,0.0009619678,0.003806179,0.0001582051,0.00006035597,0.00003332518,0.003826524,0.0002471512,0.001578331],"genre_scores_gemma":[0.9851521,0.0006608376,0.003285951,0.0001369361,0.00001570932,0.0000733646,0.003413605,0.0001001879,0.007161158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002054132,"threshold_uncertainty_score":0.00687176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005918145138850707,"score_gpt":0.2134222584460363,"score_spread":0.2075041133071856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}