{"id":"W1584908757","doi":"10.1186/ar1416","title":"Differential gene expression and regulation of the bone morphogenic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts","year":2004,"lang":"en","type":"article","venue":"Arthritis Research","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital du Sacré-Cœur de Montréal; Université de Montréal; Hôpital Notre-Dame","funders":"Canadian Arthritis Network; School of Medicine, University of California, San Diego; Menzies Institute for Medical Research; National Cancer Institute; Arthritis Society; University of North Carolina at Chapel Hill; Genentech; National Institutes of Health; Biogen; Lupus Research Institute; Pfizer; Natural Sciences and Engineering Research Council of Canada; Dutch Arthritis Association; Oesterreichische Nationalbank; Deutsche Forschungsgemeinschaft; Nuffield Foundation; Physiotherapy Foundation of Canada; Canadian Institutes of Health Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Lupus Research Alliance; Wellcome Trust; Newcastle University; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; Austrian Science Fund; Arthritis Foundation","keywords":"Follistatin; Noggin; Internal medicine; Bone morphogenetic protein; Endocrinology; Transforming growth factor; Growth factor; Angiogenin; Chordin; Cartilage; Bone morphogenetic protein 4; Biology; Chemistry; Medicine; Angiogenesis; Anatomy; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000336658,0.0001322691,0.0001750057,0.0001307137,0.0002618001,0.0000716882,0.00009192625,0.0001197742,0.00001462359],"category_scores_gemma":[0.0002523853,0.0001173997,0.00002278255,0.0001352466,0.0006754246,0.00002064783,0.0005235043,0.0002246524,4.534205e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001813325,"about_ca_system_score_gemma":0.00008117019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003008005,"about_ca_topic_score_gemma":0.001933,"domain_scores_codex":[0.9983904,0.0002616969,0.0002308524,0.0004337793,0.0003380229,0.0003452128],"domain_scores_gemma":[0.9994599,0.0000518294,0.00004484907,0.0002225566,0.0001086316,0.0001122546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001926832,0.00003980543,0.01161016,0.00008295688,0.00000619097,0.00001087703,0.0001699695,0.000001365424,0.9828507,0.0001463994,0.000005426174,0.004883463],"study_design_scores_gemma":[0.002785507,0.0005991046,0.1610953,0.0002657645,0.000001683213,0.00007361089,0.00006455695,0.00001168879,0.8342723,0.000677385,0.00004167915,0.0001113823],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950367,0.0040145,0.00002262614,0.0001507704,0.00001270591,0.0007027237,0.00003642751,0.000003681337,0.0000199159],"genre_scores_gemma":[0.9988988,0.000667176,0.0001963841,0.000003160199,0.00005119762,0.00005748741,0.00002688455,0.00001821282,0.00008066736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1494852,"threshold_uncertainty_score":0.4787419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01600677292520453,"score_gpt":0.2900552633790343,"score_spread":0.2740484904538298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}