{"id":"W1585152828","doi":"10.4049/jimmunol.192.supp.201.5","title":"Targeting IL-6/STAT3 pathway with small-molecule compounds for multiple sclerosis therapy (THER6P.849)","year":2014,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Multiple sclerosis; STAT3; Myelin; Autoimmunity; Experimental autoimmune encephalomyelitis; Immune system; Biology; Immunology; Glycoprotein 130; Adoptive cell transfer; Pathogenesis; Cell biology; Phosphorylation; Cancer research; T cell; Neuroscience; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008161788,0.0003875454,0.0002141961,0.0002244185,0.0001031839,0.0001842218,0.0001522271,0.0002847518,0.002262468],"category_scores_gemma":[0.00002727547,0.00008147285,0.0002800344,0.0001358108,0.0001204174,0.0001047985,0.0001528511,0.0005414431,0.000629577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002382696,"about_ca_system_score_gemma":0.0002512658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003026714,"about_ca_topic_score_gemma":0.0007677114,"domain_scores_codex":[0.9999639,0.000004767899,0.000002529591,0.000005419126,0.00001195664,0.00001148054],"domain_scores_gemma":[0.9999839,0.000001372772,0.000006025275,0.000001050236,0.000002001235,0.000005620091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003751233,0.0002794628,0.0001597755,0.0002583745,0.00002281384,0.00009917007,0.00001164364,0.0007755646,0.9752931,0.0005869125,0.0007199487,0.0214182],"study_design_scores_gemma":[0.0006619152,0.005848854,0.002267574,0.0000415563,0.00007638244,0.0005292091,0.0000110069,0.002429619,0.9668602,0.0002122437,0.02104342,0.00001794874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9373827,0.02798397,0.01579214,0.0009151055,0.0003110263,0.0006892213,0.00212231,0.0005845871,0.01421894],"genre_scores_gemma":[0.9685863,0.009755951,0.0103226,0.0003251166,0.00003948896,0.0004111698,0.001300539,0.0000192817,0.009239565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002262468,"threshold_uncertainty_score":0.007568717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0468705628560748,"score_gpt":0.252642664725691,"score_spread":0.2057721018696162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}