{"id":"W1585410256","doi":"10.1113/jphysiol.2012.240390","title":"Peroxisome proliferator‐activated receptor γ coactivator 1‐α gene transfer restores mitochondrial biomass and improves mitochondrial calcium handling in post‐necrotic <i>mdx</i> mouse skeletal muscle","year":2012,"lang":"en","type":"article","venue":"The Journal of Physiology","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Université de Montréal; Université du Québec à Montréal","funders":"Canadian Institutes of Health Research","keywords":"Mitochondrion; Mitochondrial permeability transition pore; Duchenne muscular dystrophy; Skeletal muscle; Biology; Coactivator; Muscular dystrophy; Endocrinology; Cell biology; Peroxisome proliferator-activated receptor; Internal medicine; Downregulation and upregulation; Receptor; Biochemistry; Medicine; Transcription factor; Genetics; Gene; Programmed cell death; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000266718,0.000283344,0.0004244226,0.000103108,0.0001563765,0.00001366993,0.000304623,0.0003269801,0.00002983065],"category_scores_gemma":[0.0001840006,0.0001990234,0.0001597339,0.000108358,0.0003566404,0.00004530673,0.00009184721,0.0003945099,0.000004533764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002569368,"about_ca_system_score_gemma":0.0001445489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006378233,"about_ca_topic_score_gemma":0.00001802753,"domain_scores_codex":[0.9980559,0.0005403343,0.0004878151,0.0002541202,0.0001378618,0.0005240081],"domain_scores_gemma":[0.9990873,0.0001122015,0.0002042398,0.0002849253,0.0001399792,0.0001713014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003271822,0.000275251,0.0001900787,0.00002724166,0.00014982,8.195737e-7,0.0003791534,0.00002532746,0.9949607,0.00001640016,0.0005325158,0.000170928],"study_design_scores_gemma":[0.002690543,0.001278309,0.01328009,0.00001499165,0.00005959937,0.00003713844,0.0002991966,0.00000788176,0.9806561,0.00006422774,0.001353568,0.0002583408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964926,0.001746972,0.0001495086,0.0002316264,0.001022976,0.000315068,0.00002507082,0.000007731582,0.000008482448],"genre_scores_gemma":[0.9972479,0.0002977422,0.0002180341,0.0003072407,0.001811987,0.00001589504,0.00004000285,0.00003647014,0.00002473469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01430453,"threshold_uncertainty_score":0.8115938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009996809237103102,"score_gpt":0.2381669323746997,"score_spread":0.2281701231375965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}