{"id":"W1585854655","doi":"10.4137/bci.s2850","title":"Prolonged Treatment with Free Fatty Acids has Post Receptor Effect in Hepatic Insulin Resistance: Evidence that Fatty Acids, Oleate and Palmitate have Insignificant Effect on the Insulin Receptor Beta<i>In Vivo</i>and<i>Ex Vivo</i>primary Hepatocytes","year":2009,"lang":"en","type":"article","venue":"Biochemistry Insights","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; University Health Network; Mount Sinai Hospital","funders":"","keywords":"Internal medicine; Endocrinology; Insulin resistance; Insulin; Insulin receptor; Protein kinase B; Fatty acid; Phosphorylation; In vivo; PI3K/AKT/mTOR pathway; Tyrosine phosphorylation; Stimulation; Chemistry; Ex vivo; Receptor; Biology; Biochemistry; Signal transduction; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001836061,0.000374689,0.0004650858,0.0001839201,0.0001706289,0.000340158,0.0001454218,0.0003514352,0.002670592],"category_scores_gemma":[0.000151362,0.000187992,0.000490838,0.0001823442,0.0003513118,0.0003523518,0.000273718,0.0007776301,0.000518664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001818018,"about_ca_system_score_gemma":0.0001523731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003144176,"about_ca_topic_score_gemma":0.0007190045,"domain_scores_codex":[0.9998156,0.00004389237,0.00002446725,0.00003863383,0.00003009923,0.00004724965],"domain_scores_gemma":[0.9997959,0.0000285641,0.00004846491,0.00005048948,0.00001913065,0.00005746262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001729225,0.00008834938,0.0005138127,0.00006875139,0.00002641105,0.00009369988,0.00002035956,0.00001797071,0.9956161,0.00002864023,0.00003056842,0.001766103],"study_design_scores_gemma":[0.00006911158,0.003470422,0.01418513,0.00001290919,0.00006446264,0.0004702445,0.00009952599,0.0001305026,0.9796824,0.00005360245,0.001753136,0.0000085044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934471,0.004339349,0.001009262,0.0001546343,0.00007133957,0.00001169032,0.0001738929,0.00003396927,0.0007588466],"genre_scores_gemma":[0.9938725,0.001954506,0.0008671011,0.0001341777,0.00003130031,0.0000320074,0.0004037682,0.00002240938,0.002682276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002670592,"threshold_uncertainty_score":0.008934021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01818430163801527,"score_gpt":0.2349468984072597,"score_spread":0.2167625967692445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}