{"id":"W1585854655","doi":"10.4137/bci.s2850","title":"Prolonged Treatment with Free Fatty Acids has Post Receptor Effect in Hepatic Insulin Resistance: Evidence that Fatty Acids, Oleate and Palmitate have Insignificant Effect on the Insulin Receptor Beta<i>In Vivo</i>and<i>Ex Vivo</i>primary Hepatocytes","year":2009,"lang":"en","type":"article","venue":"Biochemistry Insights","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; University Health Network; Mount Sinai Hospital","funders":"","keywords":"Internal medicine; Endocrinology; Insulin resistance; Insulin; Insulin receptor; Protein kinase B; Fatty acid; Phosphorylation; In vivo; PI3K/AKT/mTOR pathway; Tyrosine phosphorylation; Stimulation; Chemistry; Ex vivo; Receptor; Biology; Biochemistry; Signal transduction; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004035558,0.0009611173,0.001184113,0.0001736672,0.0002607821,0.0001579146,0.000283273,0.0003163864,0.00004445994],"category_scores_gemma":[0.0003221952,0.0005521651,0.0001887227,0.000366955,0.0004254006,0.0001975667,0.00009502214,0.0004436569,0.00001806496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008377293,"about_ca_system_score_gemma":0.0002953118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002114041,"about_ca_topic_score_gemma":0.0001925503,"domain_scores_codex":[0.9963032,0.0004338196,0.0006010512,0.001319089,0.0006900089,0.0006528366],"domain_scores_gemma":[0.996659,0.001309967,0.0003206282,0.001150884,0.000115357,0.0004441917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01749348,0.002265288,0.6642639,0.001102668,0.0005240851,0.0008668785,0.002643223,0.000001963553,0.3033644,0.00001717891,0.0004880576,0.006968895],"study_design_scores_gemma":[0.008734907,0.006610546,0.245274,0.004147929,0.000373503,0.00001358843,0.0001034536,0.00001689244,0.7337991,0.00002660373,0.0003905294,0.0005089724],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9749969,0.01763544,9.960634e-7,0.003225798,0.00006133231,0.003432426,0.0001853951,0.00009107391,0.0003706231],"genre_scores_gemma":[0.9908145,0.006768806,0.0001704763,0.0008479767,0.0001114018,0.0009478828,0.0001506925,0.00005883026,0.0001294392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4304347,"threshold_uncertainty_score":0.999693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01818430163801527,"score_gpt":0.2349468984072597,"score_spread":0.2167625967692445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}