{"id":"W1586375807","doi":"10.1111/j.1538-7836.2012.04715.x","title":"Targeted gene inactivation reveals a functional role of calpain‐1 in platelet spreading","year":2012,"lang":"en","type":"article","venue":"Journal of Thrombosis and Haemostasis","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Merck Canada; School of Medicine, New York University; Howard Hughes Medical Institute","keywords":"Calpain; RHOA; CDC42; Platelet; Cell biology; RAC1; Lamellipodium; Chemistry; Cytoskeleton; Platelet activation; Hemostasis; Biology; GTPase; Molecular biology; Biochemistry; Signal transduction; Immunology; Cell; Medicine; Internal medicine; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005000602,0.00008207971,0.0001834614,0.0001207514,0.00003987929,0.000008442523,0.00003602415,0.0001077149,0.00004796587],"category_scores_gemma":[0.00009113111,0.00006963557,0.00007910877,0.0001068857,0.00003356704,0.00002370555,0.00002544438,0.00007863622,5.321137e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002898121,"about_ca_system_score_gemma":0.00002984497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001626424,"about_ca_topic_score_gemma":0.000003042999,"domain_scores_codex":[0.9992441,0.0000681005,0.0003424146,0.00008193331,0.0001414278,0.0001220029],"domain_scores_gemma":[0.9994211,0.00001904959,0.000292884,0.00007447519,0.0001189832,0.00007350466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002117089,0.0001167573,0.05297274,0.00001697202,0.00008813593,2.389393e-7,0.0001447235,0.0000951051,0.9380828,0.00008289776,0.001160157,0.007027774],"study_design_scores_gemma":[0.0008465963,0.0001759236,0.3446176,0.00004524789,0.00003154016,0.00003944475,0.0003273217,0.00006183968,0.6488792,0.0001786179,0.004698923,0.00009778876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996882,0.001388174,0.001230373,0.0001899452,0.0001393998,0.00008171018,0.00000733689,0.000001590428,0.00007947606],"genre_scores_gemma":[0.9983923,0.000389345,0.0008301574,0.00008384995,0.0002420057,0.00000243826,0.00002332066,0.000008487445,0.00002809488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2916448,"threshold_uncertainty_score":0.2839656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02638022105266516,"score_gpt":0.2698479987290033,"score_spread":0.2434677776763382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}