{"id":"W1586805947","doi":"10.1158/0008-5472.can-13-0080","title":"Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institute on Aging; National Institute of General Medical Sciences; Wellcome Trust","keywords":"Metformin; Glutamine; Prostate cancer; Cancer cell; Cancer; Internal medicine; Endocrinology; Metabolism; Carbohydrate metabolism; Medicine; Cancer research; Biology; Chemistry; Biochemistry; Diabetes mellitus; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001197315,0.0002765979,0.0002183645,0.0002670588,0.0001206753,0.0002291234,0.0001548983,0.0001721927,0.000739592],"category_scores_gemma":[0.0001232985,0.0001242653,0.0002250626,0.0002243826,0.0001315586,0.0001481828,0.0001830174,0.0003727691,0.00009775911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002302012,"about_ca_system_score_gemma":0.0003317881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008819972,"about_ca_topic_score_gemma":0.001941557,"domain_scores_codex":[0.9998994,0.00002518659,0.000008877107,0.00001320069,0.00002811311,0.00002526165],"domain_scores_gemma":[0.9999057,0.00001484054,0.00003466989,0.000009637347,0.00001144374,0.00002372448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002806518,0.00004062494,0.0007074084,0.00003342992,0.00001239771,0.00002981402,0.000006826798,0.0000947316,0.9959736,0.0001207532,0.00003766851,0.00266207],"study_design_scores_gemma":[0.00003856657,0.001015064,0.0174688,0.000009714984,0.00003156761,0.0001961185,0.00002389516,0.0006652991,0.9778291,0.0001079658,0.002606199,0.000007602745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946263,0.0025931,0.001301796,0.0001423737,0.00003204671,0.0000161446,0.0002544269,0.00005154544,0.0009822176],"genre_scores_gemma":[0.9948977,0.001945584,0.001937627,0.00006960343,0.000008703728,0.00001947119,0.000292895,0.00001154091,0.0008169136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008819972,"threshold_uncertainty_score":0.002474248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02513318733462448,"score_gpt":0.3329481174391847,"score_spread":0.3078149301045602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}