{"id":"W1586897675","doi":"10.4049/jimmunol.1400472","title":"TLR2 Stimulation Regulates the Balance between Regulatory T Cell and Th17 Function: A Novel Mechanism of Reduced Regulatory T Cell Function in Multiple Sclerosis","year":2015,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Neurological Disorders and Stroke; Medical Research Council","keywords":"TLR2; FOXP3; Multiple sclerosis; Regulatory T cell; Stimulation; Immunology; Function (biology); Pathogenesis; Proinflammatory cytokine; T cell; Experimental autoimmune encephalomyelitis; Mechanism (biology); Biology; Cell biology; Inflammation; IL-2 receptor; Neuroscience; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002444658,0.0005453174,0.0004307112,0.0003078047,0.0002467781,0.0004927529,0.0001993901,0.0004809588,0.001284791],"category_scores_gemma":[0.0001350681,0.0001603674,0.0003279552,0.0001565929,0.0004041702,0.0003631237,0.0002741246,0.0006368464,0.0004343319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002420925,"about_ca_system_score_gemma":0.0002022418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001407255,"about_ca_topic_score_gemma":0.0001886123,"domain_scores_codex":[0.9997544,0.00006457607,0.0000196852,0.00005125233,0.00004138516,0.00006882135],"domain_scores_gemma":[0.9999344,0.000007832598,0.00001804884,0.00000798071,0.00001023717,0.00002148904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000705614,0.00007548931,0.002048122,0.0001360124,0.00001960956,0.0002811377,0.00003271948,0.00008465019,0.9911431,0.0002288188,0.0001430665,0.005101668],"study_design_scores_gemma":[0.0002491071,0.00212826,0.06766926,0.00008057148,0.0001590802,0.005494566,0.0003266177,0.002910948,0.9107319,0.001476781,0.00873422,0.00003869742],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820394,0.01198955,0.003374347,0.000405705,0.0001060055,0.0000296763,0.0002044557,0.00009314854,0.001757614],"genre_scores_gemma":[0.9956328,0.001777089,0.001028972,0.0001608528,0.00008716604,0.00003125997,0.0001247282,0.00001406219,0.001143095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001284791,"threshold_uncertainty_score":0.004298031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.031360719005095,"score_gpt":0.206403930440748,"score_spread":0.175043211435653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}