{"id":"W1587434408","doi":"10.1007/978-0-387-73657-0_180","title":"Design, Selection and Binding Mechanism of Bivalent Miniproteins Targeting Human Thrombin","year":2009,"lang":"en","type":"article","venue":"Advances in experimental medicine and biology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Biological Sciences; Biotechnology Research Institute","funders":"","keywords":"Bivalent (engine); Chemistry; Biophysics; Computational biology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003506012,0.0003536907,0.0003219202,0.0002471996,0.0002509582,0.0004726077,0.0005658314,0.0003489609,0.000627603],"category_scores_gemma":[0.0003614608,0.000348691,0.0002442908,0.0002278188,0.0002234826,0.0002203446,0.000316007,0.0005253354,0.0003605442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004614805,"about_ca_system_score_gemma":0.000155845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005301499,"about_ca_topic_score_gemma":0.0005913625,"domain_scores_codex":[0.9997481,0.00005181798,0.00002811891,0.00005653161,0.0000725627,0.00004287266],"domain_scores_gemma":[0.999832,0.00002965181,0.00004102691,0.00001678617,0.00003370857,0.00004674334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005508016,0.00001559205,0.00009571182,0.00001488862,0.000003827859,0.00002013752,0.00001871363,0.0001552552,0.9983494,0.0001817514,0.00004006307,0.001049591],"study_design_scores_gemma":[0.00001120209,0.000108476,0.0004272343,0.00000239356,0.00001352625,0.00009536083,0.00001530377,0.001876621,0.9954484,0.00003498123,0.001960379,0.000006200831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9656813,0.0007134904,0.03213388,0.0001269624,0.00003687295,0.0001140569,0.0001495677,0.0001283368,0.0009156266],"genre_scores_gemma":[0.9737753,0.0005334456,0.02151538,0.0001399148,0.00001116885,0.0001079311,0.0005331837,0.00005592368,0.003327745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000627603,"threshold_uncertainty_score":0.003348231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06271838711977303,"score_gpt":0.412468475111886,"score_spread":0.349750087992113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}