{"id":"W1587500999","doi":"10.1002/jcp.24459","title":"Calnexin Silencing in Mouse Neonatal Cardiomyocytes Induces Ca<sup>2+</sup> Cycling Defects, ER Stress, and Apoptosis","year":2013,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Heart and Stroke Foundation; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Unfolded protein response; Endoplasmic reticulum; Calnexin; ATF6; Apoptosis; Gene silencing; Cell biology; Caspase 12; XBP1; Thapsigargin; Biology; Chemistry; Caspase; Molecular biology; Programmed cell death; Biochemistry; Calreticulin; RNA splicing","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001358382,0.0002054067,0.0003772069,0.0001082318,0.00005786267,0.00003327723,0.0001888263,0.0001904345,0.0000367569],"category_scores_gemma":[0.0001305317,0.0001704262,0.0001689135,0.00006550027,0.0001245582,0.00002331284,0.0001289066,0.0002464703,0.000006288831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001986715,"about_ca_system_score_gemma":0.00008298697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001790121,"about_ca_topic_score_gemma":0.000005933187,"domain_scores_codex":[0.9986932,0.0001617511,0.0004230971,0.0002683612,0.0001389095,0.0003146959],"domain_scores_gemma":[0.9992254,0.00004964388,0.000226873,0.0002042525,0.0001198397,0.0001739635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007492674,0.00005772516,0.003636192,0.00006135729,0.00008052192,0.00001785557,0.0001664676,0.005246748,0.9899035,0.00001101193,0.0002076759,0.0005359853],"study_design_scores_gemma":[0.001124412,0.0002879316,0.003330727,0.0000701911,0.00004548959,0.00003458226,0.00114095,0.000932775,0.992362,0.0002089922,0.0002102755,0.0002516868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953739,0.004150938,0.0001254815,0.00005147643,0.00008595681,0.0001188632,0.00001786281,0.000003583612,0.00007192671],"genre_scores_gemma":[0.9984208,0.0007627506,0.0002402554,0.00011172,0.0003563236,0.00001025921,0.00003526779,0.0000213662,0.00004125633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004313973,"threshold_uncertainty_score":0.6949777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005489259046436463,"score_gpt":0.2104104418418966,"score_spread":0.2049211827954601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}