{"id":"W1587951878","doi":"10.4049/jimmunol.176.7.4479","title":"Iodination of Tyrosyls in Thyroglobulin Generates Neoantigenic Determinants That Cause Thyroiditis","year":2006,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Thyroid Disorders and Treatments","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Thyroglobulin; Autoimmune thyroiditis; Thyroiditis; Peptide; Iodine; Halogenation; Chemistry; Thyroid; Immunology; Endocrinology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001462569,0.0001930793,0.0002198391,0.0002560304,0.0001237674,0.0002225844,0.0001370536,0.0001391606,0.0002161332],"category_scores_gemma":[0.0001724765,0.0001101115,0.0002184369,0.0002252404,0.0001405243,0.0001144991,0.0001568646,0.0001545258,0.0000791188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001677157,"about_ca_system_score_gemma":0.0001638177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003065521,"about_ca_topic_score_gemma":0.0006269323,"domain_scores_codex":[0.9999312,0.00001173549,0.000006264295,0.00001684477,0.00001950839,0.00001429098],"domain_scores_gemma":[0.9999061,0.0000231349,0.00003388907,0.00001548214,0.000009294863,0.00001217555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00013528,0.00001504732,0.002711432,0.0000313561,0.000009026568,0.00005750336,0.00002191822,0.0008179547,0.9912902,0.0001090979,0.00001341112,0.004787736],"study_design_scores_gemma":[0.00002158918,0.0006519984,0.01542345,0.000009441144,0.00006219804,0.0008702623,0.00005578253,0.01238691,0.9689915,0.0002347621,0.001283288,0.000008803498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944695,0.0001492938,0.005030117,0.000007322997,0.000001749634,0.00001068867,0.00002852715,0.00002938729,0.0002733272],"genre_scores_gemma":[0.983403,0.0002191189,0.01589125,0.0000138178,0.000001978967,0.000009227309,0.0001670124,0.00001520418,0.0002793317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003065521,"threshold_uncertainty_score":0.001216829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0158283266415475,"score_gpt":0.2616279457832613,"score_spread":0.2457996191417137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}