{"id":"W1588091866","doi":"10.1158/1538-7445.am2014-1881","title":"Abstract 1881: New therapeutic options for CLL treatment: Src/c-abl-directed molecular re-engineering of chlorambucil and bendamustine","year":2014,"lang":"en","type":"article","venue":"Cancer Research","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; Concordia University; Royal Victoria Regional Health Centre; McGill University; Jewish General Hospital","funders":"","keywords":"Chlorambucil; Chronic lymphocytic leukemia; Fludarabine; Cancer research; Dasatinib; Nitrogen mustard; Bendamustine; Medicine; Pharmacology; Imatinib; Leukemia; Chemistry; Immunology; Chemotherapy; Cyclophosphamide; Internal medicine; Myeloid leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001092527,0.0003415019,0.0002627186,0.000243695,0.00006973405,0.0002597036,0.0001927833,0.0002856108,0.001673211],"category_scores_gemma":[0.00005471973,0.00009250243,0.0002177976,0.000135669,0.0001088759,0.0001928322,0.000160017,0.0005383306,0.0004669357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003131432,"about_ca_system_score_gemma":0.000122813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003080002,"about_ca_topic_score_gemma":0.0004825608,"domain_scores_codex":[0.9999337,0.00001059069,0.000005055597,0.00001247579,0.00001913717,0.00001899564],"domain_scores_gemma":[0.9999791,0.000002091049,0.000006622186,0.000001769061,0.000003465569,0.000006880745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000439568,0.0001839486,0.0002295328,0.0002490547,0.00002942035,0.0001264811,0.0000306949,0.0007844783,0.9560199,0.0009889517,0.0008936248,0.04002447],"study_design_scores_gemma":[0.0005211529,0.002526886,0.003512283,0.00004189189,0.0001311657,0.001214638,0.00002592585,0.002184541,0.9062329,0.0002546564,0.08332433,0.00002970563],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9320509,0.04099268,0.01091136,0.001186136,0.0003467503,0.0003979772,0.001036303,0.0003056388,0.0127722],"genre_scores_gemma":[0.9715613,0.01180366,0.008804973,0.000391007,0.00006351196,0.0001585943,0.001125476,0.00004705525,0.006044498],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.001673211,"threshold_uncertainty_score":0.005597472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09612360987829247,"score_gpt":0.4126559270655814,"score_spread":0.3165323171872889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}