{"id":"W1589197782","doi":"10.2119/molmed.2011.00306","title":"Hematopoietic CC-Chemokine Receptor 2 (CCR2) Competent Cells Are Protective for the Cognitive Impairments and Amyloid Pathology in a Transgenic Mouse Model of Alzheimer’s Disease","year":2011,"lang":"en","type":"article","venue":"Molecular Medicine","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Canadian Institutes of Health Research; Universitätsklinikum Regensburg; Canada Research Chairs; Alzheimer Society","keywords":"CCR2; Genetically modified mouse; Chemokine receptor; Molecular medicine; Transgene; Chemokine; Receptor; Disease; Pathology; Alzheimer's disease; Medicine; Biology; Immunology; Internal medicine; Gene; Cell cycle; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002209923,0.0001905141,0.0002770677,0.000122042,0.00007031175,0.000005287885,0.0001461451,0.00004517111,0.00003313069],"category_scores_gemma":[0.0002728061,0.0001373694,0.00006523978,0.0001573588,0.0002526657,0.0000516774,0.00003973281,0.0001429368,0.000003064322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000104002,"about_ca_system_score_gemma":0.00003574454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004115619,"about_ca_topic_score_gemma":0.000003441652,"domain_scores_codex":[0.9985291,0.0002038894,0.0003661832,0.0004285803,0.0002575878,0.0002146022],"domain_scores_gemma":[0.9992467,0.0001194326,0.0001951313,0.0002313532,0.00007960188,0.0001277903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003054261,0.0003226302,0.000007564691,0.00004715214,0.000008843654,0.00002776911,0.001544426,0.00007340158,0.9968582,0.0006424634,0.000008306561,0.0001537883],"study_design_scores_gemma":[0.004457297,0.0003801166,0.0001332385,0.00005947613,0.0000975666,0.000007713947,0.0002082292,0.0114462,0.9821914,0.0008931622,0.000004557591,0.0001209893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9432884,0.0001217486,0.05320846,0.0008824742,0.00009800329,0.00225155,0.00008633544,0.00003259445,0.00003035814],"genre_scores_gemma":[0.9974397,0.00007232041,0.0003265672,0.001704432,0.00001455521,0.0003628264,0.000005446609,0.00003026178,0.00004388462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05415123,"threshold_uncertainty_score":0.560176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0628777576074306,"score_gpt":0.2683573328406991,"score_spread":0.2054795752332685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}