{"id":"W1589317871","doi":"10.1016/s0076-6879(07)31013-6","title":"Identifying Small Molecule Inhibitors of Eukaryotic Translation Initiation","year":2007,"lang":"en","type":"review","venue":"Methods in enzymology on CD-ROM/Methods in enzymology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Translation (biology); Eukaryotic translation; Computational biology; Small molecule; Chemistry; Biology; Biochemistry; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008349565,0.00192855,0.001975299,0.001933214,0.0002999467,0.001108828,0.001361768,0.001145744,0.002107011],"category_scores_gemma":[0.00061262,0.0007533281,0.0005432638,0.001413734,0.0007492622,0.00117079,0.0008055757,0.00253534,0.002803474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009401374,"about_ca_system_score_gemma":0.0006870757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006516709,"about_ca_topic_score_gemma":0.001236848,"domain_scores_codex":[0.9997146,0.00002597119,0.00002166839,0.0000451964,0.000149304,0.00004327238],"domain_scores_gemma":[0.9997327,0.0001136221,0.00005320265,0.00001298305,0.00006432849,0.00002315923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001472029,0.0002341323,0.0001585226,0.005295408,0.00008903371,0.0002655534,0.0000393353,0.001226204,0.04190628,0.006840375,0.02050818,0.9232897],"study_design_scores_gemma":[0.0002407926,0.0004157232,0.0008962735,0.0009943033,0.0001982812,0.00138671,0.0000294693,0.001442347,0.08319046,0.0039471,0.90719,0.00006855839],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002544187,0.977141,0.01221739,0.0004835194,0.0005556312,0.0001256479,0.0001637208,0.0002616923,0.006507063],"genre_scores_gemma":[0.01274827,0.9656751,0.009427992,0.0007846185,0.0003580367,0.0002323437,0.0005606455,0.00003678673,0.01017631],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002107011,"threshold_uncertainty_score":0.007048726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.163812194253755,"score_gpt":0.4605912501181237,"score_spread":0.2967790558643687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}