{"id":"W1589357932","doi":"10.1186/ar1380","title":"Insights into systemic lupus erythematosus pathogenesis through blood global gene expression analysis","year":2004,"lang":"en","type":"article","venue":"Arthritis Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Arthritis Network; School of Medicine, University of California, San Diego; Menzies Institute for Medical Research; National Cancer Institute; Arthritis Society; University of North Carolina at Chapel Hill; Genentech; National Institutes of Health; Biogen; Lupus Research Institute; Pfizer; Natural Sciences and Engineering Research Council of Canada; Dutch Arthritis Association; Oesterreichische Nationalbank; Deutsche Forschungsgemeinschaft; Nuffield Foundation; Physiotherapy Foundation of Canada; Canadian Institutes of Health Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Lupus Research Alliance; Wellcome Trust; Newcastle University; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; Austrian Science Fund; Arthritis Foundation","keywords":"Immunology; Peripheral blood mononuclear cell; Pathogenesis; Rheumatoid arthritis; Cytokine; Gene; Significance analysis of microarrays; Microarray analysis techniques; Biology; Microarray; Gene signature; Gene expression; Medicine; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006103775,0.0003117455,0.0007789651,0.0004950698,0.0006978899,0.0001163038,0.0004270559,0.0002522039,0.0002761447],"category_scores_gemma":[0.0002353018,0.0002475819,0.0004500061,0.00311985,0.0004738861,0.0002305178,0.0004823521,0.0005878962,0.000626869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002970067,"about_ca_system_score_gemma":0.0004829807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002272383,"about_ca_topic_score_gemma":0.0008100607,"domain_scores_codex":[0.9945787,0.0004146969,0.000603918,0.0008815661,0.002468401,0.001052739],"domain_scores_gemma":[0.997484,0.0001922053,0.00007109918,0.0008790887,0.0007820027,0.0005916464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001624675,0.002192111,0.2464373,0.0008973359,0.002218083,0.0121118,0.003726861,0.0002843117,0.7005767,0.01094121,0.001762033,0.01722762],"study_design_scores_gemma":[0.02979016,0.006267703,0.07725286,0.00598793,0.001519673,0.02171403,0.005074488,0.000380269,0.7601742,0.06756058,0.02172957,0.002548565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9605246,0.03271988,0.0006043977,0.001072013,0.0001381504,0.0006934973,0.00004796265,0.00009867403,0.004100804],"genre_scores_gemma":[0.9791862,0.0145143,0.00440786,0.0001173543,0.000426288,0.0001580291,0.0001425376,0.00003645105,0.001010946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1691844,"threshold_uncertainty_score":0.9999976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03809806468890337,"score_gpt":0.351624625649638,"score_spread":0.3135265609607347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}