{"id":"W1589408448","doi":"10.1038/ncb3201","title":"An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes","year":2015,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":250,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa; University of Manitoba; Western University; Alberta Children's Hospital","funders":"National Cancer Institute; Wellcome Trust; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; Howard Hughes Medical Institute; Medical Research Council; Biotechnology and Biological Sciences Research Council; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Rosetrees Trust; Canadian Institutes of Health Research; National Institute of Neurological Disorders and Stroke; National Institute for Health and Care Research; Action Medical Research","keywords":"Ciliogenesis; Ciliopathy; Ciliopathies; Cilium; Biology; Genetics; Joubert syndrome; Cell biology; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003446726,0.0008443467,0.0006416985,0.0007784943,0.0005394048,0.0004941077,0.0005751484,0.0007330893,0.002665532],"category_scores_gemma":[0.000278202,0.0003544402,0.0006564476,0.0002833715,0.0004740981,0.0001736064,0.0003481152,0.0007230458,0.00102834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006966186,"about_ca_system_score_gemma":0.0006940333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002058542,"about_ca_topic_score_gemma":0.005890658,"domain_scores_codex":[0.9996386,0.00004591953,0.00003968695,0.00007293214,0.0001533043,0.00004969135],"domain_scores_gemma":[0.9997844,0.00008016425,0.0000410302,0.00002003348,0.0000318112,0.0000425452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000302139,0.00001460911,0.00005211122,0.00001462097,0.00000657435,0.00006859736,0.000003521943,0.00005805665,0.9992641,0.00006273734,0.00006234619,0.0003625521],"study_design_scores_gemma":[0.00004775377,0.000159689,0.002370139,0.000005031218,0.00007189167,0.0004706677,0.00002046268,0.00167192,0.992638,0.00005930952,0.002473601,0.00001135771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9373087,0.002029561,0.04244149,0.001075684,0.0002621049,0.0005772063,0.006755437,0.001236024,0.008313682],"genre_scores_gemma":[0.9652366,0.001116942,0.01933157,0.000757107,0.00002960438,0.0002394791,0.005348885,0.0003026251,0.007637189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002665532,"threshold_uncertainty_score":0.008917034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01048113568852632,"score_gpt":0.2439769149879714,"score_spread":0.233495779299445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}