{"id":"W1589408448","doi":"10.1038/ncb3201","title":"An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes","year":2015,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":250,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa; University of Manitoba; Western University; Alberta Children's Hospital","funders":"National Cancer Institute; Wellcome Trust; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; Howard Hughes Medical Institute; Medical Research Council; Biotechnology and Biological Sciences Research Council; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Rosetrees Trust; Canadian Institutes of Health Research; National Institute of Neurological Disorders and Stroke; National Institute for Health and Care Research; Action Medical Research","keywords":"Ciliogenesis; Ciliopathy; Ciliopathies; Cilium; Biology; Genetics; Joubert syndrome; Cell biology; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000276682,0.00009668527,0.0001222337,0.00003577345,0.00003975521,0.000004187722,0.0001523009,0.0002964703,0.00000325774],"category_scores_gemma":[0.00009723269,0.00007150728,0.00006939124,0.0000608197,0.0001798091,0.000001713863,0.00003010542,0.00004016122,3.270149e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000543233,"about_ca_system_score_gemma":0.0001769976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009928444,"about_ca_topic_score_gemma":0.000007820465,"domain_scores_codex":[0.9993163,0.00005758263,0.0002221382,0.0002384473,0.00005993405,0.0001056312],"domain_scores_gemma":[0.9991554,0.00003369556,0.000161539,0.0003027791,0.0002696622,0.00007692455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000298921,0.00005141824,0.00607884,0.00002348595,0.00002821684,4.878995e-8,0.00001037654,0.0004682676,0.9910397,0.00004998903,0.0005719163,0.001378814],"study_design_scores_gemma":[0.0006203892,0.0003587758,0.01818264,0.000001548853,0.00006646854,0.000001193655,0.00009712428,0.0006664057,0.9699868,0.0002006072,0.009730913,0.00008710677],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795363,0.01399706,0.005623813,0.0000885585,0.0001888532,0.0002221461,0.0003108475,0.000003779351,0.00002867643],"genre_scores_gemma":[0.9982322,0.0001396751,0.0007417739,0.0001447387,0.000142273,0.0000181939,0.0005236824,0.00001035912,0.00004710241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02105288,"threshold_uncertainty_score":0.2915982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01048113568852632,"score_gpt":0.2439769149879714,"score_spread":0.233495779299445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}