{"id":"W1590106902","doi":"10.1038/cdd.2015.94","title":"Loss of Drosophila i-AAA protease, dYME1L, causes abnormal mitochondria and apoptotic degeneration","year":2015,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Genetics; National Heart, Lung, and Blood Institute","keywords":"Intermembrane space; Cell biology; Neurodegeneration; Biology; Mitochondrion; AAA proteins; Proteases; Reactive oxygen species; Unfolded protein response; Apoptosis; Proteostasis; Oxidative stress; Programmed cell death; Bacterial outer membrane; Biochemistry; Endoplasmic reticulum; ATPase; Enzyme; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006541883,0.0001152076,0.0001212431,0.0000454795,0.00005275241,0.00002312764,0.00003621382,0.0001389621,0.00001368273],"category_scores_gemma":[0.00006738117,0.0001050137,0.0000277515,0.00003537529,0.00004237701,0.000009286066,0.00003903528,0.00004485023,0.000002888262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005206919,"about_ca_system_score_gemma":0.00004311663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001329969,"about_ca_topic_score_gemma":0.0000139854,"domain_scores_codex":[0.999326,0.0000669376,0.0001738804,0.0002308687,0.00008528087,0.0001170458],"domain_scores_gemma":[0.9995283,0.000006885945,0.00009263821,0.0001345833,0.00009293525,0.0001445923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001885431,0.00006995348,0.03903393,0.00005550729,0.00001248022,0.000001265203,0.0001130409,0.00003286035,0.95925,0.0003994439,0.0005619296,0.0002810676],"study_design_scores_gemma":[0.002329641,0.0007450425,0.03343116,0.0000140947,0.00008074863,0.00003676825,0.00006471552,0.0006406671,0.9597021,0.0006316821,0.002051219,0.0002722018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910191,0.0006326503,0.007316386,0.0000375751,0.0003456069,0.000230291,0.00001384123,0.000008497565,0.0003961035],"genre_scores_gemma":[0.9979658,0.0001521997,0.0006078254,0.00007215737,0.0002514784,0.00002024141,0.0003193503,0.000009896085,0.0006011025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006946701,"threshold_uncertainty_score":0.4282336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01738286541318102,"score_gpt":0.230836038186821,"score_spread":0.21345317277364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}