{"id":"W1590133931","doi":"10.5772/25347","title":"Involvement of Microglial Cathepsin B in Pro-Interleukin-1 Processing and Persistent Pain","year":2012,"lang":"en","type":"book-chapter","venue":"InTech eBooks","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Core Research for Evolutional Science and Technology; Ministerio de Educación, Cultura y Deporte; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Inflammasome; Microglia; Cathepsin; Cathepsin B; Endosome; Cell biology; Proinflammatory cytokine; Cathepsin S; Caspase 1; Chemistry; Neuroinflammation; Proteolysis; Caspase; Pyroptosis; Lysosome; Biology; Inflammation; Biochemistry; Programmed cell death; Receptor; Apoptosis; Immunology; Intracellular","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026406,0.0004550317,0.0004021562,0.0004518541,0.0002754075,0.000429752,0.0002606244,0.0008330958,0.001572661],"category_scores_gemma":[0.0002764643,0.0001625653,0.0006212241,0.0002394098,0.0004125037,0.0004590881,0.0003740719,0.000528144,0.000348872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003500856,"about_ca_system_score_gemma":0.0003753436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007243072,"about_ca_topic_score_gemma":0.0004212804,"domain_scores_codex":[0.9998141,0.00004402608,0.00002146276,0.00002366794,0.00003004993,0.000066747],"domain_scores_gemma":[0.9998606,0.00001285126,0.00005620516,0.000009501921,0.00002105232,0.00003968486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0156333,0.0009909096,0.01728025,0.007660165,0.0007008412,0.02481961,0.0008809374,0.0006343485,0.8390592,0.004582267,0.00422692,0.08353121],"study_design_scores_gemma":[0.003821669,0.009566438,0.4612817,0.001250209,0.001885148,0.07631081,0.002450848,0.008108029,0.3444492,0.01595566,0.07466516,0.0002552883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7644234,0.2231944,0.002590692,0.002459714,0.0005138258,0.0001098433,0.000338207,0.00009940526,0.006270465],"genre_scores_gemma":[0.9779251,0.01963701,0.000562623,0.0002125102,0.0001686883,0.00005153523,0.0001368942,0.000004682378,0.001300979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001572661,"threshold_uncertainty_score":0.005261123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01462052155695454,"score_gpt":0.2241550964286025,"score_spread":0.2095345748716479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}