{"id":"W1590133931","doi":"10.5772/25347","title":"Involvement of Microglial Cathepsin B in Pro-Interleukin-1 Processing and Persistent Pain","year":2012,"lang":"en","type":"book-chapter","venue":"InTech eBooks","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Core Research for Evolutional Science and Technology; Ministerio de Educación, Cultura y Deporte; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Inflammasome; Microglia; Cathepsin; Cathepsin B; Endosome; Cell biology; Proinflammatory cytokine; Cathepsin S; Caspase 1; Chemistry; Neuroinflammation; Proteolysis; Caspase; Pyroptosis; Lysosome; Biology; Inflammation; Biochemistry; Programmed cell death; Receptor; Apoptosis; Immunology; Intracellular","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003414309,0.0002643546,0.0002674406,0.0001135728,0.00002906411,0.00001476742,0.00016152,0.0003475891,0.00001550704],"category_scores_gemma":[0.00001744638,0.0002577638,0.0001583587,0.000005795913,0.0001896413,0.000001913728,0.0001703551,0.0002056071,0.000002861851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003419023,"about_ca_system_score_gemma":0.0001035162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000288573,"about_ca_topic_score_gemma":0.0001155641,"domain_scores_codex":[0.9989752,0.00002532731,0.0003658046,0.0002970959,0.0001068698,0.0002297167],"domain_scores_gemma":[0.9994405,0.000005370149,0.0001922067,0.0002445372,0.00007796826,0.00003945233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001092695,0.00002905025,0.0001275736,0.0002673767,0.0000962057,0.000003842862,0.0007761808,8.709636e-8,0.9073241,0.0001443368,0.0000601369,0.09106188],"study_design_scores_gemma":[0.0005883225,0.0005342169,0.00001409229,0.0006267063,0.00006048135,0.00001466137,0.0004900083,0.000003828435,0.8265936,0.0003561757,0.1702835,0.0004343845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4801338,0.05525625,0.0006687921,0.0001634815,0.0005095737,0.002826656,0.0001142319,0.00005254115,0.4602747],"genre_scores_gemma":[0.9284338,0.0001841524,0.0001506373,0.0001538505,0.0001001258,0.00003477228,0.00007390821,0.00005539792,0.07081341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4483,"threshold_uncertainty_score":0.9999875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01462052155695454,"score_gpt":0.2241550964286025,"score_spread":0.2095345748716479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}