{"id":"W1590504688","doi":"10.1158/1538-7445.am2014-3804","title":"Abstract 3804: CPA-7, an inhibitor of STAT3, is a potent tumoricidal agent in peripheral tumor models and is impermeable to the CNS","year":2014,"lang":"en","type":"article","venue":"Cancer Research","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Survivin; Glioma; Cancer research; STAT3; Cisplatin; Apoptosis; Medicine; Biology; Chemistry; Molecular biology; Chemotherapy; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001083613,0.0006128831,0.0003109346,0.0003604605,0.0001893971,0.0002427873,0.0003084451,0.0003053556,0.005060101],"category_scores_gemma":[0.00009852042,0.0001374298,0.0002321769,0.0002252683,0.0002732289,0.000249925,0.0001934964,0.0009768384,0.001179273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003926254,"about_ca_system_score_gemma":0.0003946733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007581218,"about_ca_topic_score_gemma":0.0007450901,"domain_scores_codex":[0.9998544,0.00002491589,0.000008340127,0.00002213986,0.00006086138,0.00002924531],"domain_scores_gemma":[0.9998976,0.0000182268,0.00002302154,0.0000107296,0.00002258397,0.00002789035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002452698,0.00007927594,0.0001051829,0.00009077744,0.00001211655,0.00004404311,0.000005921262,0.00009970179,0.9952578,0.0001305015,0.0003038227,0.003625639],"study_design_scores_gemma":[0.00003452936,0.0006998534,0.0008228499,0.000004898416,0.00001650726,0.0002688007,0.000004335835,0.0005533493,0.9946208,0.00002825708,0.00294351,0.000002407314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9708273,0.007635735,0.01111785,0.0004309675,0.0001160561,0.0001490958,0.001752643,0.0005093435,0.007461041],"genre_scores_gemma":[0.9784861,0.002654781,0.00582415,0.00009763215,0.00004018633,0.0001311474,0.003011917,0.00007025248,0.009683894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005060101,"threshold_uncertainty_score":0.01692772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2743382566298365,"score_gpt":0.5091478968132257,"score_spread":0.2348096401833892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}