{"id":"W1590680891","doi":"10.1111/j.1747-0285.2010.00970.x","title":"Computational Design and Biological Testing of Highly Cytotoxic Colchicine Ring A Modifications","year":2010,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Allard Foundation","keywords":"Colchicine; Tubulin; Paclitaxel; Cytotoxicity; Microtubule; Computational biology; Chemistry; Biology; Biochemistry; In vitro; Cell biology; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005099008,0.0007876629,0.0008829706,0.0005102365,0.0003955443,0.0007186476,0.0009511168,0.000917202,0.002403984],"category_scores_gemma":[0.001710858,0.0003954947,0.0005554924,0.0004556452,0.0005371153,0.0003964937,0.0003929154,0.0006443897,0.000185036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00118409,"about_ca_system_score_gemma":0.001635438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006178187,"about_ca_topic_score_gemma":0.009730654,"domain_scores_codex":[0.9998689,0.00004443399,0.000006470007,0.00002438725,0.00002750426,0.00002829356],"domain_scores_gemma":[0.9989152,0.0008330014,0.00006443493,0.0000343356,0.0001077615,0.00004526219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002188335,0.0001137504,0.001152968,0.000143841,0.00004611799,0.0001347165,0.00001932561,0.9888635,0.001872574,0.001398756,0.0003589985,0.00567655],"study_design_scores_gemma":[0.00009324044,0.0002535004,0.0002079836,0.000008408902,0.00003530092,0.00001597514,0.0000333714,0.9960564,0.001827912,0.0008567083,0.0006054286,0.000005668799],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9572939,0.0009999537,0.02324356,0.0005824556,0.00008266329,0.0002124442,0.0009430182,0.0004552008,0.01618689],"genre_scores_gemma":[0.9686885,0.0003148479,0.02836685,0.0001717191,0.0000103727,0.0002287526,0.0007848647,0.00005130123,0.001382687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006178187,"threshold_uncertainty_score":0.01228446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04292656675375719,"score_gpt":0.2762849898960876,"score_spread":0.2333584231423304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}