{"id":"W1590680891","doi":"10.1111/j.1747-0285.2010.00970.x","title":"Computational Design and Biological Testing of Highly Cytotoxic Colchicine Ring A Modifications","year":2010,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Allard Foundation","keywords":"Colchicine; Tubulin; Paclitaxel; Cytotoxicity; Microtubule; Computational biology; Chemistry; Biology; Biochemistry; In vitro; Cell biology; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003388029,0.0001535111,0.0001983982,0.00003834648,0.00007117382,0.000008693715,0.0001743742,0.0002326609,0.000009424129],"category_scores_gemma":[0.0001818347,0.0001322322,0.00004428992,0.00009785513,0.0003249463,0.000002282311,0.00008442858,0.0001707222,0.000002331416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007039114,"about_ca_system_score_gemma":0.00008052176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006340241,"about_ca_topic_score_gemma":6.395993e-7,"domain_scores_codex":[0.9990337,0.00008343171,0.000246324,0.0003739665,0.00004932395,0.0002132626],"domain_scores_gemma":[0.9992439,0.0002474437,0.0001060051,0.0001949454,0.000117316,0.00009036563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008232993,0.00005864682,0.000229193,0.000005384967,0.00003462643,4.84599e-7,0.00002189552,0.000286408,0.9948652,0.00227853,0.000061315,0.002075971],"study_design_scores_gemma":[0.0005183169,0.0002049311,0.0001643579,0.000006968211,0.00001889095,0.00002495002,0.00001026094,0.004696101,0.9864875,0.007206649,0.0005025297,0.000158526],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7852366,0.0002177013,0.2139854,0.0001386623,0.00006703062,0.0002486459,0.00001643592,0.00001912428,0.00007037781],"genre_scores_gemma":[0.883225,0.0000316949,0.1163259,0.000176812,0.0001027453,0.0000457829,0.00006140057,0.00001261538,0.00001808156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09798837,"threshold_uncertainty_score":0.5392272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04292656675375719,"score_gpt":0.2762849898960876,"score_spread":0.2333584231423304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}