{"id":"W1590717714","doi":"10.1161/hyp.62.suppl_1.a488","title":"Abstract 488: Atorvastatin Inhibits Src/ROS-mediated Redox Sensitive And Pro-Inflammatory Actions of Aldosterone in Vascular Smooth Muscle Cells: Focus on Statins Pleiotropic Effects","year":2013,"lang":"en","type":"article","venue":"Hypertension","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Atorvastatin; Aldosterone; Geranylgeranylation; Vascular smooth muscle; Statin; Mevalonate pathway; Internal medicine; Endocrinology; Angiotensin II; P22phox; Phosphorylation; NADPH oxidase; Chemistry; Pharmacology; Oxidative stress; Biology; Biochemistry; Medicine; Prenylation; Receptor; Biosynthesis; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008937226,0.0002842658,0.000432859,0.0001380951,0.0001549567,0.0001933567,0.0002290151,0.0002608496,0.004754173],"category_scores_gemma":[0.00006238536,0.00008303036,0.0003374451,0.0001359329,0.00021653,0.000164496,0.0001390362,0.0007155628,0.0007336204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001373869,"about_ca_system_score_gemma":0.0003268506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007452968,"about_ca_topic_score_gemma":0.001641548,"domain_scores_codex":[0.9998844,0.0000179388,0.00001120024,0.00001341296,0.00002461071,0.00004849763],"domain_scores_gemma":[0.9999567,0.000005398795,0.000006901226,0.000005051925,0.000007585104,0.0000182251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001149571,0.000193291,0.0002168331,0.0002196245,0.00002489269,0.00007878093,0.00001835234,0.000037216,0.9935328,0.0001450124,0.0004057594,0.003977875],"study_design_scores_gemma":[0.0002662136,0.002869164,0.01109299,0.0000213947,0.00007387008,0.0002751703,0.00005769941,0.0004693415,0.9790304,0.00009954345,0.005737299,0.000006915559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837624,0.007721189,0.001837419,0.0007696098,0.0002078807,0.00007246173,0.001116192,0.0001669825,0.004345858],"genre_scores_gemma":[0.9835488,0.005231996,0.001362648,0.0002242913,0.0001094422,0.00007819265,0.001152119,0.00001968197,0.00827286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004754173,"threshold_uncertainty_score":0.01590431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01808039262501779,"score_gpt":0.2322543366741007,"score_spread":0.2141739440490829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}