{"id":"W1591231287","doi":"10.1002/jnr.23338","title":"Mitochondrial lactate metabolism is involved in antioxidative defense in human astrocytoma cells","year":2014,"lang":"en","type":"article","venue":"Journal of Neuroscience Research","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Laurentian University","funders":"","keywords":"Pyruvate dehydrogenase complex; Biochemistry; Oxidative stress; Oxidative phosphorylation; Lactate dehydrogenase; Pyruvate decarboxylation; Mitochondrion; Chemistry; Metabolism; Pyruvate carboxylase; Reactive oxygen species; Lactate dehydrogenase A; Pyruvate dehydrogenase kinase; Biology; Glycolysis; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00166741,0.0001071794,0.0002260283,0.0005296716,0.00009260966,0.00005426712,0.000435106,0.0001143268,0.00002043718],"category_scores_gemma":[0.0008867137,0.0000925308,0.00008657483,0.0005672121,0.0002618871,0.00002176493,0.0001341228,0.0005627682,0.000007750698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002338369,"about_ca_system_score_gemma":0.0001660455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002083982,"about_ca_topic_score_gemma":0.0001008273,"domain_scores_codex":[0.9974098,0.0009165031,0.000423303,0.000323818,0.0004993844,0.0004271536],"domain_scores_gemma":[0.9991475,0.00006750287,0.0001547067,0.0002275485,0.0002570024,0.0001456756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003235553,0.00008953329,0.001311379,0.000004452786,0.000001403742,0.00004308611,0.0001168595,0.00005974303,0.9963747,0.00006683583,0.001395286,0.0002131499],"study_design_scores_gemma":[0.002134626,0.001772407,0.01723902,0.00002730393,0.000003168332,0.00006720432,0.0001443969,0.0001721702,0.9416614,0.0003760536,0.03626648,0.0001357509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975637,0.00005256526,0.0006764808,0.0003201876,0.0008327196,0.0001331765,0.000003452155,0.0000016208,0.0004161463],"genre_scores_gemma":[0.9980795,0.0001338433,0.0005351788,0.0003448849,0.000462529,0.000004195939,0.000001249126,0.00001089183,0.0004277162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0547133,"threshold_uncertainty_score":0.3773297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05701881461912284,"score_gpt":0.3600310883526359,"score_spread":0.303012273733513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}