{"id":"W1591654527","doi":"10.1002/path.4569","title":"Recurrent <i><scp>DICER1</scp></i> hotspot mutations in endometrial tumours and their impact on <scp>microRNA</scp> biogenesis","year":2015,"lang":"en","type":"article","venue":"The Journal of Pathology","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; BC Cancer Agency","funders":"National Cancer Institute; U.S. Public Health Service","keywords":"microRNA; Biogenesis; Biology; Cancer research; Genetics; Gene; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001492618,0.0002356476,0.0003295079,0.0003335844,0.00006621057,0.00002459483,0.0002951601,0.000184167,0.000002565658],"category_scores_gemma":[0.001619766,0.0001473945,0.0001740777,0.0002897429,0.0001926885,0.00001168596,0.00009694808,0.0002341084,0.000008158033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007498255,"about_ca_system_score_gemma":0.0002469121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000159037,"about_ca_topic_score_gemma":0.00002387505,"domain_scores_codex":[0.9982063,0.0006302171,0.0004782457,0.0002005285,0.0001677423,0.000317005],"domain_scores_gemma":[0.9983799,0.0003783684,0.0005378344,0.000279329,0.0002196641,0.0002049388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002411303,0.000204954,0.01040628,0.000009107701,0.0001005767,0.00006765973,0.001019299,0.0007784571,0.9790593,0.00001468377,0.006390206,0.001708374],"study_design_scores_gemma":[0.007682706,0.004997013,0.2327928,0.0001003578,0.0002874553,0.00483458,0.003025993,0.0001033395,0.7363407,0.001644944,0.008023006,0.000167066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922459,0.006388473,0.000354779,0.0001356141,0.0004120209,0.0002015565,0.00009939091,0.000005005826,0.0001572217],"genre_scores_gemma":[0.9984875,0.0006620311,0.0001536071,0.0001316045,0.0004534472,0.000004745325,0.00003927777,0.00002719707,0.00004055179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2427186,"threshold_uncertainty_score":0.6010571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02041281288242851,"score_gpt":0.2789704674336853,"score_spread":0.2585576545512568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}