{"id":"W1591698220","doi":"10.1002/art.38121","title":"Brief Report: Fibrosis Caused by Loss of PTEN Expression in Mouse Fibroblasts Is Crucially Dependent on CCN2","year":2013,"lang":"en","type":"article","venue":"Arthritis & Rheumatism","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research; Scleroderma Society of Ontario","keywords":"PTEN; Tensin; Fibrosis; CTGF; Connective tissue; Cancer research; CYR61; Pathology; Matricellular protein; Myofibroblast; Sirius Red; Medicine; Growth factor; Biology; Extracellular matrix; PI3K/AKT/mTOR pathway; Signal transduction; Internal medicine; Cell biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002133912,0.0002272143,0.0003148091,0.0001072803,0.00006783826,0.00005170698,0.0002716742,0.0002105087,0.0007853094],"category_scores_gemma":[0.0003069057,0.0002388358,0.00009253147,0.0001122494,0.0001164074,0.0000249824,0.0002403493,0.0001707252,0.0000704416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003750209,"about_ca_system_score_gemma":0.00007578668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001685793,"about_ca_topic_score_gemma":0.0006556856,"domain_scores_codex":[0.9978783,0.0001395531,0.0005470698,0.0005967192,0.0004205702,0.0004177543],"domain_scores_gemma":[0.9987812,0.00005757579,0.0001946268,0.0006580401,0.0001581463,0.0001503933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004413385,0.0001293921,0.008715004,0.00003032156,0.00002487669,0.00003513425,0.0002157952,0.00000842146,0.9567165,0.00001667712,0.01348101,0.0205827],"study_design_scores_gemma":[0.001285135,0.0004060986,0.02512165,0.0004764741,0.000001663774,0.00003640992,0.00004683618,0.00001844328,0.9705164,0.0001615016,0.001666045,0.0002633106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996527,0.001669809,0.0002371055,0.0002594233,0.00006270509,0.000545212,0.0001374304,0.0000173653,0.0005439828],"genre_scores_gemma":[0.9966228,0.001360342,0.0002466965,0.00007761287,0.00002571452,0.0001241311,0.0001372452,0.0000437168,0.001361749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02031939,"threshold_uncertainty_score":0.9739442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009221486904305264,"score_gpt":0.2524172468323119,"score_spread":0.2431957599280067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}