{"id":"W1591698220","doi":"10.1002/art.38121","title":"Brief Report: Fibrosis Caused by Loss of PTEN Expression in Mouse Fibroblasts Is Crucially Dependent on CCN2","year":2013,"lang":"en","type":"article","venue":"Arthritis & Rheumatism","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research; Scleroderma Society of Ontario","keywords":"PTEN; Tensin; Fibrosis; CTGF; Connective tissue; Cancer research; CYR61; Pathology; Matricellular protein; Myofibroblast; Sirius Red; Medicine; Growth factor; Biology; Extracellular matrix; PI3K/AKT/mTOR pathway; Signal transduction; Internal medicine; Cell biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004618019,0.0006517299,0.0002417788,0.0004223639,0.0003262696,0.0003223028,0.0003789654,0.0006552687,0.007314072],"category_scores_gemma":[0.0002115914,0.0001760048,0.0002365419,0.0002650652,0.0002581299,0.0002144332,0.000234375,0.0005781829,0.002134163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002800328,"about_ca_system_score_gemma":0.0002461094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002081951,"about_ca_topic_score_gemma":0.0002989048,"domain_scores_codex":[0.999736,0.00003108418,0.00003505382,0.00005786501,0.00009544277,0.00004448982],"domain_scores_gemma":[0.9996693,0.00006258269,0.00007286389,0.00002392349,0.00005651132,0.0001148367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006973209,0.0001016039,0.0005491864,0.0005393311,0.00002372291,0.002013115,0.00004204435,0.00009475653,0.9725856,0.0006785051,0.01001095,0.01266391],"study_design_scores_gemma":[0.000156981,0.001090598,0.00760549,0.00004991195,0.0001243515,0.008128049,0.00006741066,0.0004704975,0.8503177,0.0003363032,0.1316285,0.00002414279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.757142,0.1048272,0.03357127,0.01470467,0.01908926,0.0005724388,0.008262034,0.001725209,0.06010597],"genre_scores_gemma":[0.8456194,0.04211171,0.01011226,0.001556123,0.01024154,0.000295172,0.007765961,0.0001771268,0.08212075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007314072,"threshold_uncertainty_score":0.02446806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009221486904305264,"score_gpt":0.2524172468323119,"score_spread":0.2431957599280067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}